title: Antibody helps detect protein implicated in alzheimers other diseases

text:
A team of researchers has found a way to measure tau levels in the blood. The method accurately reflects levels of tau in the brain that correlate with neurological damage. The study, in mice and a small group of people, could be the first step toward a noninvasive test for tau.
The study was published in Science Translational Medicine.
The researchers say that such a test potentially could be used to quickly screen for tau-based diseases, monitor disease progression and measure the effectiveness of treatments designed to target tau.
Tau is a normal brain protein involved in maintaining the structure of neurons. But when tau forms tangles, it damages and kills nearby neurons. A blood-based screening test, likely years away, would be a relatively easy way to identify people whose symptoms may be due to problems with tau, without subjecting them to potentially invasive, expensive or complicated tests.
In the brain, most tau proteins are inside cells, some are in tangles, and the remainder float in the fluid between cells. Such fluid constantly is being washed out of the brain into the blood, and tau comes with it. However, the protein is cleared from the blood almost as soon as it gets there, so the levels, while detectable, typically remain very low.
The team reasoned that if they could keep tau in the blood longer, the protein would accumulate to measurable levels. Allowing the protein to accumulate before measuring its levels would magnify – but not distort – differences between individuals, in the same way that enlarging a picture of a grain of sand alongside a grain of rice does not change the relative size of the two, but does make it easier to measure the difference between them.
The researchers injected a known amount of tau protein directly into the veins of mice and monitored how quickly the protein disappeared from the blood. The researchers showed that half the protein normally disappears in less than nine minutes. When they added an antibody that binds to tau, the half-life of tau was extended to 24 hours.
To determine whether the antibody could amplify tau levels in an animal’s blood high enough to be measured easily, they injected the antibody into mice. Within two days, tau levels in the mice’s blood went up into the easily detectable range. The antibody acted like a magnifying glass, amplifying tau levels so that differences between individuals could be seen more easily.
Tau levels in people’s blood also rose dramatically in the presence of the antibody. The researchers administered the antibody to four people with a tau disease known as progressive supranuclear palsy. Their blood levels of tau rose 50- to 100-fold within 48 hours.
Measuring tau levels in the blood is only useful if it reflects tau levels in the brain, where the protein does its damage, the researchers said.
Both high and low levels of tau in the fluid that surrounds the brain could be a danger sign. Alzheimer’s and chronic traumatic encephalopathy both are associated with high levels of soluble tau, whereas progressive supranuclear palsy and other genetic tau diseases are thought to be associated with low levels.
To see whether elevated brain tau is reflected in the blood, the researchers treated mice with a chemical that injures neurons. The chemical causes tau to be released from the dying neurons, thereby raising tau levels in the fluid surrounding the cells. The scientists saw a corresponding increase of tau in the blood in the presence of the anti-tau antibody.
Paper: “Anti-tau antibody administration increases plasma tau in transgenic mice and patients with tauopathy”
Reprinted from materials provided by Washington University School of Medicine.


tier: cub

shelf: software-docs

title: Crane getting misty eyed

text:
It might be one of the most common side effects of the common cold, along with that endlessly runny nose, but thanks to Crane‘s critter-shaped cool mist humidifiers, getting misty can be part of the cure instead.
In room humidifiers are one of the best homeopathic, non-medicated ways to relieve nasal congestion during cough, cold and flu season, which is currently upon us full blast in some form or another, but believe it or not, many parents shy away from using one, since it usually brings up images of those clunky, space-taking, not saving, models grandma used to use.
That’s where Crane‘s fun-meets-function concept comes in. The company has been crafting cool mist humidifiers since 2005 that are just for the swingset crowd, meaning that there’s uniquely designed styles depicting everything from Hello Kitty to Thomas the Tank Engine, to Spongebob Squarepants and a sweet Elephant just to name a few.
Better yet, each one gallon water tank in the humidifier runs whisper quiet (I tried it, and was pleasantly surprised to find it’s true – all baby will hear is a super-soft hum) for up to 11 hours, and has an auto off function for when the tank runs out of gas, so to speak.
Cool air output also means curious hands won’t get burned (that alone should leave parents breathing easier), and the tank is removable, making it easy to store under most standard bathroom sinks. The easy-to-access design makes it even easier for parents to clean, which in my mind, lets everyone sleep a little better at night.


shelf: health

title: 16409

text:
The UK is experiencing unusually large scabies outbreaks and doctors encourage people to seek medical treatment if they notice red dots on their body and not to ignore the symptoms.
As an itchy rash, scabies is caused by mites that spreads through close skin contact. Early treatment is crucial to stop the spreading. Anyone can be affected by it.
Some of the common symptoms are intense itching, especially at night, and a raised rash or spots.
Scabies typically leads to a rash across the body, not including the head and neck, and often appears between fingers, around wrists, waist, underarms, groin, and bottom.
The elderly, young children, and those with weakened immune systems can get scabies on the head, palms, neck, and soles. In immunocompromised individuals, a highly contagious form called crusted scabies may cause a flaky rash on elbows, knees, hands, and feet.
As per NHS, the number of cases of people affected by the infection who were diagnosed in hospitals around the country is over 3,600.
Prof Kamila Hawthorne, RCGP chairwoman, shared that many people who experience the symptoms refuse to seek medical help because of the “social stigma” surrounding the infection. She said that the number of GP diagnoses was “above the five-year average and rising, with the north of England seeing a spike in cases.”
“While not a serious condition, scabies can be very itchy and irritating,” she said.
“If not properly treated, it can spread and increase a patient’s risk of complications, such as secondary skin infections or make existing skin conditions worse.”
One of the reasons for the scabies outbreak, in spite of the social stigma attached to it, is the shortage of treatment.
Please SHARE this article with your family and friends on Facebook.


shelf: finance

text:
TradeTracker continues its global expansion into Argentina
TradeTracker is continuously growing at a fast pace as part of its global expansion plan. With operations delivering outstanding results for advertisers and affiliates in all existing markets – and the introduction of a Real-Attribution model – the time has come to enter the third Latin-American country, Argentina. The new office will serve its products to advertisers and affiliates from Buenos Aires, starting on the 26th of November.
The expansion has led to TradeTracker currently providing its cutting-edge services to numerous markets around the world, having the widest coverage of all affiliate networks in Europe. Simultaneous to its European market take-over, it is also expanding globally to 4 continents and 24 offices. The network opens its doors with programs for top brands such as TomTop, Zaful, Naturgy, Quilmes and Aliexpress.
Start of Argentina
Country Manager for TradeTracker Argentina, Ted Vendramin, states: “It is a great pleasure to be able to offer services in Argentina with the international, transparent and effective services of TradeTracker. Launching a full and transparent first-class solution for performance marketing, we expect to provide both publishers and customers with personalized attention – and generate greater profitability. We expect to change the digital landscape with our Real-Attribution functionality, helping merchants understand the journey of their users and publishers to be rewarded for their real contribution of each sale.”
Philip Keckeis, Director of International Operations, continues: “Argentina plays an important role in Latin America and the market is consistently developing at rapid pace. We’ve now confirmed the need for a professional and transparent performance marketing network – and with attribution taking a more prominent role in the plans of brands, TradeTracker is an excellent partner which is now offering its services in this great country.”


shelf: education

title: Alex 44

text:
Rick, this reminds me a lot of Bye Bye Bird. In fact, the spacing of the lyrics in relation to the licks seems to fall on the same beats. I think practicing this is going to give me better ears on figuring out that song.
Absolutely. This is also a Sonnyboy 2 song. I got the idea of doing the song like this from a version he did on a European LP
I think it's really important to be able to tongue block single notes from either side. Then it allows you to switch with a wide mouth. So if you're jumping large intervals of many holes, you don't move the harp as far or even at all. You just move your tongue to switch between holes 1 and 4 for example.
Rick you are such a monster on the harp. I hope to be able to entertain with just a harmonica, my voice and a strong sense of groove. Hope you're doing well.
I spent a lot of time with your videos about a year ago and got as much as I could then. Now I'm going back through and picking the fruit that used to be out of reach. Kingsnake was transformative for me. I polished every note and beat of that tune. Sinking my teeth a little deeper into this one now.
Thanks Alex - I'm glad you're catching on to what I'm trying to show you. That groove can make whatever you play, feel right.
Yeah, I have to say, this lesson has been fantastic.
Finally have made it this far.
Great! Are you enjoying it?
Hey Rick, unrelated to this lesson but do you think you'll ever post any chromatic lessons?
I hadn't thought about it, but maybe. For now, you should check out Dennis's Moan a Chrom serie.
This lesson has been transformative for me. Please play in New York soon.
Wow - Thanks Alex! I'm glad it's helping you. No telling when we'll be in NY again. We did a couple NY dates last month. You can always check rickestrin.com to see where we are.
Forgot your password? Click here


shelf: home-craft

title: Universal monsters select creature from the black lagoon

text:
This figure is so good that it’s convinced me that we don’t have enough aquatic characters in our toy collections.
Sure, there’s Namor, Aquaman, Mer-Man and his redeco in blue. Black Manta. And….? Has anyone ever had a figure submerged in a fish tank for any extended amount of time? That’s what the Universal Monsters Select Creature From The Black Lagoon makes me want to do, set up a fish tank to display him and whoever else I can think of who needs to be underwater.
Like I said in the Son of Frankenstein review, Diamond Select is knocking it out of the park with this line. Great sculpting, nice paint, and abundant articulation. The Creature is no exception. In fact, I think I like him even more than Frankenstein.
The sculpt is absolutely fantastic. There isn’t a spot I can look at and not see some tiny detail. Well, okay, maybe the top of his head, but you know what I mean. The bottom of the feet even has sculpted details. Amazing. And that praise goes for paint too. Nice colors and shading combined with a glossy look makes the Creature look wet and kind of nasty. Like any good Creature should look.
When I first picked this figure up at TRU I thought he was missing some points of articulation, mainly in the ankles, thighs, and biceps. I could see that the elbows were hinge and swivel so I wasn’t too worried there, but I was afraid the legs were going to be near statue-like. Nope, DST did an awesome job of hiding the swivels at the thigh and bicep, and the Creature even has rocker ankles although limited by the sculpt that effectively hides it. Here’s my video review breaking down the articulation.
And some close-ups of the hidden swivels.
This Toys R Us exclusive comes with a more simple base than the Diamond exclusive version, but I was surprised at how many paint app were incorporated into the little piece of beach.
Add all of that together and you get one hell of a Creature from the Black Lagoon figure.
Like I said before, I’m not a huge Universal Monsters fan, but I love great action figures. And value. $14.99 for this is plastic value we haven’t seen in a while. So go buy this. Now. Go.


shelf: history-culture

text:
Discover Exquisite Mooncake Packaging: Find Reasonably Priced Boxes at Global Sources!
The Mid-Autumn Festival, a time for family reunions and lunar appreciation, is incomplete without the indulgence of delectable mooncakes. While the taste and texture of mooncakes play a crucial role, the presentation is equally significant. Enter mooncake packaging—the enchanting boxes that not only protect these delicacies but also elevate the entire gifting experience. In this article, we will explore the fascinating world of mooncake packaging and introduce you to a comprehensive list of exquisite mooncake boxes available at Global Sources. Get ready to unlock a treasure trove of packaging options from verified wholesalers and manufacturers worldwide, all at reasonable prices!
The Essence of Mooncake Packaging
Mooncake packaging embodies the spirit of tradition and aesthetics, showcasing the cultural significance of this beloved festival. The exquisite craftsmanship, intricate designs, and choice of materials make these boxes more than just containers; they become works of art. Mooncake boxes come in various shapes, sizes, and materials, ranging from classic tin boxes to eco-friendly paper packaging. Whether you prefer a traditional or contemporary design, the right mooncake packaging enhances the gift’s allure and conveys your heartfelt wishes.
A World of Choices at Your Fingertips
Global Sources, a renowned online platform, serves as a gateway to a vast array of mooncake packaging options. The platform features verified wholesalers and manufacturers from several countries, ensuring the highest quality and authenticity. With a user-friendly interface and comprehensive search filters, Global Sources makes your mooncake packaging exploration effortless and enjoyable. From exploring the latest trends to finding unique packaging solutions, this website has it all.
Catering to Every Requirement
At Global Sources, you will find an extensive range of mooncake boxes, tailored to meet various preferences and needs. Whether you’re a confectionery business owner looking for packaging solutions or an individual wanting to impress your loved ones, this platform has you covered. Here’s a glimpse of the diverse mooncake packaging options available:
- Traditional Elegance: Explore classic tin boxes adorned with intricate patterns, reminiscent of the festival’s cultural heritage. These boxes exude elegance and nostalgia, making them a timeless choice.
- Contemporary Chic: Embrace modern aesthetics with sleek and minimalist mooncake boxes. These designs focus on simplicity, featuring clean lines and innovative materials, making them perfect for those seeking a contemporary touch.
- Eco-Friendly Alternatives: With sustainability on the rise, Global Sources offers eco-friendly packaging options made from recycled or biodegradable materials. These boxes allow you to showcase your commitment to the environment while delighting your recipients.
- Customization Galore: Tailor your mooncake packaging to match your brand or personal preferences. Global Sources connects you with manufacturers who offer customization services, allowing you to create unique boxes with your desired logo, colors, and designs.
Value for Money
Global Sources understands the importance of affordability without compromising on quality. The mooncake packaging products showcased on their platform come at reasonable prices, ensuring you get the best value for your investment. By directly connecting with verified wholesalers and manufacturers, you can enjoy competitive pricing without sacrificing the quality and craftsmanship you deserve.
As the Mid-Autumn Festival approaches, it’s time to immerse yourself in the enchanting world of mooncake packaging. With Global Sources as your trusted guide, you can embark on a delightful journey to find the perfect mooncake boxes. From traditional elegance to contemporary chic, eco-friendly alternatives to customization options, the platform offers a full-scale list of choices from verified wholesalers and manufacturers. Don’t miss the opportunity to enhance your gifting experience and delight your loved ones with exquisite mooncake packaging. Visit Global Sources today and uncover a world of packaging possibilities that satisfy all your requirements at reasonable prices!


shelf: civic-law

title: News

text:
The goal of the conference is to bring together world-renowned and early-career researchers working in the field of algebraic geometry, low-dimensional topology, complex geometry and commutative algebra and foster discussions around singularities in topology, metric geometry, algebraic geometry, dynamical systems and mirror symmetry. The meeting also seeks to provide an opportunity for young scholars from Eastern Europe to engage with cutting edge research in the area.
Aiming to understand the relation to other "refined invariants", and especially their possible interpretation in quantum theory, we explain how to obtain a quadratic, A1-version of Donaldson-Thomas invariants from the motivic refinements first introduced in Kontsevich-Soibelman. Following ideas from Behrend, Bryan and Szendroi, we provide predictions for these invariants in a few simple examples, mainly the computation of DT invariants of A3.
Our main goal is to draw relationships with the literature, including works of Levine, Denef and Loser, Azouri, Pepin-Lehaulleur, Srinivas among others. We begin with a brief introduction to A1-enumerative geometry and in the end, we pose some further questions on possible extensions of our definitions. This is joint work with Johannes Walcher. We also comment on joint work in progress with Ran Azouri.
In this talk we will explain the role that the Lie algebras play in the construction of 6-dimensional compact quotient spaces M=G/Γ, where Γ is a lattice, endowed with an invariant complex structure with holomorphically trivial canonical bundle.
Affine geometry is sometimes described as "what remains of Euclidean geometry when distances are forgotten". In this talk, I will report on a very recent discovery of an affine-invariant notion, which may be viewed as a distance from a point inside a convex domain to its boundary. This new concept stems from a suggestion of Conan Leung, who proposed to average the canonical tropical series, a fundamental notion of tropical optics, over the manifold of all tropical structures of fixed covolume on the given affine space. Very little of what we (Nikita Kalinin, Ernesto Lupercio and me) currently know, as well as necessary preliminaries, some observations and precise conjectures, will be covered during the talk, which mainly serves as an invitation to participate in developing this exciting new topic.
On March 10, 2025, at 5 PM in the Prof. Marin Drinov Hall of the Bulgarian Academy of Sciences, Prof. Yuri Tschinkel will deliver an academic lecture on the occasion of his election as a foreign member of the Bulgarian Academy of Sciences.
Prof. Tschinkel was elected a foreign member of the Bulgarian Academy of Sciences on November 25, 2024 upon the proposal of the Scientific Council of the Institute of Mathematics and Informatics. He is a world-renowned mathematician, creator of several new directions with a huge influence on the development of modern mathematics, with a remarkable results in rational points on algebraic varieties; stable irrationality; stabilization; symbol theory; G-irrationality.
New project “International Center for Mathematical Sciences – Sofia: Pursuing excellence” for the period 2024 - 2029 funded by the Simons Foundation under Grant SFI-MPS-T-Institutes-00007697 and the Ministry of Education and Science of the Republic of Bulgaria, contract No. ДО1-239/10.12.2024


shelf: science-engineering

title: Index

text:
Jump On Board.
Tell us more about yourself and we'll keep you up-to-date regarding upcoming events and career opportunities that match your interests.
At ED USA, Corp., we're a global community of passionate individuals, with a special HUMAN CENTRIC focus, united in our diversity by sharing the same mindset and values. Our passion for exploring new possibilities push our belief that by bringing our community together we can enable meaningful change.Our values are a real source of inspiration for us to accomplish our purpose and ultimately make dreams possible together. They reflect the ED USA, Corp. mindset of constantly challenging ourselves in our collaborative innovation journey.Our working environment inspires new ideas, promotes research and experimentation, and supports highly motivated individuals to think big.
Be an innovator, not a spectator.
What we do.
ED USA greatest invention is the “I AM ED USA. We believe that through the application of intelligence, reason and science, we can improve business, society and the human condition, bringing the power of an open hybrid cloud and AI strategy to life for our clients and partners around the world. We are not only a software company, This is why our community growth every single day.Our first rule in each kind of activities is to think and to be “HUMAN CENTRIC”.
Join our Client Engineering Team.
Our Client Engineering team way of working is human-centric, with a critical focus on co-creation, co-execution, and co-operation; it’s like working in a start-up, delivering at speed but with the scale of the enterprise.
Following the page and check open jobs.
More than just work.
Our Client Engineering team way of working is human-centric, with a critical focus on co-creation, co-execution, and co-operation; it’s like working in a start-up, delivering at speed but with the scale of the enterprise.Check open jobs.
3. Online Assessments
4. Assessment Center / Interview
5. Decision / Offer
Thank you for your inquiry about employment opportunities with ED USA, Corp.
If you would like to send your resume please use the following address:
Deciding to start your career at ED USA, Corp. is an investment in your future. Whether you’re an undergraduate, graduate, or post-graduate, we’ll help you turn your years of study into tangible achievements through a vast array of global career opportunities and development programs. At ED USA, Corp., you will find a wealth of opportunities to create the career you’ve always imagined.
On how we use your personal information, please refer to our
There are currently no open positions.


title: 6 major services offered by smm panel

text:
SMM panels are in high demand nowadays. The need for social media marketing makes it really very necessary to use SMM panels for effective and efficient social media marketing.
Social media platform marketing is a major branch of the digital marketing function of an organization. Technological advancement has made it possible to outsource the whole social media marketing function to an outside third party which is referred to as an SMM panel. Today we will talk about 6 major services offered by the SMM panel.
SMM Panel: Major Services
Social Media Marketing Panels offer a variety of services which makes it very convenient to execute social media marketing activities. Let’s see 6 major services offered by the SMM Panel.
1. Maintain Your Social Media Profile
The major service that is offered by a SMM panel is maintaining your social media profile. Business marketers prefer SMM panels for maintaining their social media profile in a professional way because they are using it for the official purpose. And official and personal profiles have huge differences in terms of interface, features, themes, and activities. They hire SMM panel service to maintain their whole social media profile according to their brand image.
2. Manage Your Brand Image On The Web
These SMM panels are very useful in managing the whole brand image on the web design. Today, the buying behavior of a human being is highly influential from social media or the web. People buy every small or big product or service after deep research and analysis on social media and google. These SMM panels help in managing your brand image on the web development. These panels are responsible for the whole digital branding of your brand. They take care of every positive and negative feedback and opinion that your brand is facing on the web.
3. Advertising Of Your Products
Search engine optimization is a very important element of social media marketing. Because preparing unique and optimized online media content is only possible through search engine optimization activities. SMM panel also takes care of your content’s quality by conducting SEO audits of your social media profiles. SEO activities are also helpful in improving the overall ranking of our social media content on search engines. They use high quality algorithms and AI based tools for conducting and executing search engine optimization on our social media profiles.
5. Lead Generation
SMM Panels are highly useful for the lead generation also. Yes, It’s true, these panels aso take care of lead generation function. As it uses AI based chatbots like Manychat for maintaining the communication function of your accounts. They basically use a conversational marketing approach for generating potential leads. AI based chatbots help in pitching the interested people to buy your products and services in a professional manner. They also do follow ups on potential leads. They help in increasing the sales funnel. They do this process 24/7.
6. Increases The Audience Retention Rate At Your Social Media Content
For successful digital marketing through online media marketing we need a high number of likes, views, shares and comments. SMM panels also take care of these functions. They help in increasing the overall audience retention rate of our social media profile and its content. We execute all these social media marketing activities, advertising campaigns, lead generation model, branding and many more for our audience only. We all do this to impress our audience mainly. If we did not get audience response and support then all the efforts will go in vain and our survival will be in danger. But SMM panels are very capable in increasing the audience retention rate of our channel by improving the overall reach and hitting the target audience at the right time and at the right platform with the right strategy.
Social media marketing is a major element of today’s marketing function. SMM panels are very much capable of executing our online marketing functions efficiently and effectively and increase our overall growth and development.


title: Pediatric dentistry

text:
Pediatric dentistry is a dental specialty focused on the prevention, diagnosis, and treatment of oral health problems in children. Pediatric dentists have specific training that qualifies them to provide care for children’s teeth and gums as they change throughout childhood. Pediatric dentists provide comprehensive care, from preventative treatment like cleanings and sealants to treatment for oral disease and injuries. A pediatric dentist will also counsel parents about a child’s nutritional and hygienic habits.
Did you know…
that early childhood caries is the most common chronic disease in American children? It is far more prevalent than other common childhood illnesses, such as asthma. Furthermore, tooth decay and gum disease that begins early in life are likely to progress over time, potentially leading to a lifetime of oral complications.
Frequently Asked Questions
What ages of children do pediatric dentists treat?
A pediatric dentist will treat patients from birth through adolescence. The American Academy of Pediatric Dentistry recommends that young patients begin visiting a pediatric dentist no later than the first birthday when most children already have a first tooth. Children will continue to visit the dentist periodically throughout childhood to prevent tooth decay and gum disease.
What type of training does a pediatric dentist have?
A pediatric dentist has the same credentials as a family dentist, only with two additional years of training specifically in the oral treatment of babies, children, teens, and kids with special needs. They are trained to understand not only the dental needs of a child but also the psychological and emotional needs as well.
How can I make a pediatric dental appointment?
Our staff is happy to assist you through the process of making the first appointment for your child. Simply call our office to speak with one of our helpful staff members and schedule your child’s visit. We aim to make your child’s experience as comfortable as possible.


tier: polar

title: Microsoft finally waves the white flag on smartpho

text:
Editor's note: An earlier version of this article incorrectly stated Microsoft sold the rights to smartphones and feature phones. This article originally appeared with the headline "Microsoft Finally Waves the White Flag on Smartphones." It has been updated.
In 2014, Nokia (NOK -2.44%) effectively exited the device market when its devices and services business sale to Microsoft (MSFT -0.93%) closed for $7.2 billion. Nokia's high-end Lumia line and low-end, developing-market Asha line, along with Nokia president and CEO Stephen Elop and Nokia's manufacturing plants, supply chains, and employees, were included in the deal.
After dominating the handset market with nearly 50% market share in 2007, Nokia found itself unable to match the ascendance of Apple and Samsung, and saw its market share drop to less than 5% in late 2012 as the close relationship with Microsoft was unable to reverse Nokia's fortunes. "Microkia's" fortunes fared no better post-acquisition; new CEO Satya Nadella took a $7.6 billion writedown on the phone line and let go of 7,800 workers, most in the phone business.
Microsoft’s recent announcement represents a further step away from former CEO Steve Ballmer’s vision of being a “devices and services” company.
Microsoft steps back
According to a report from The Verge, Microsoft is selling its feature-phone business to a division of Chinese manufacturer Foxconn for $350 million. Foxconn has been aggressive about moving up the value chain in phones in order to profit from more than just assembly.
Most notable was the deal with Canadian smartphone company BlackBerry to design and distribute new BlackBerry models, with the newest models sporting Alphabet's Android operating system. With this deal, however, Foxconn will control the software in addition to the aforementioned design, assembly, and distribution.
After years of the Nokia brand being downplayed, it appears the name will be returning to devices. In the wake of Microsoft's announcement, Nokia revealed it would license its brand and IP to a Finnish company, AMD Global. Nokia, AMD Global, and Foxconn worked together to bring a tablet, the Nokia N1, to market in 2014. As a condition of the sale to Microsoft, though, Nokia was unable to enter the smartphone market until 2016
Windows Phone isn't technically dead, but...
Microsoft hasn't officially thrown in the towel on being a devices and services company. This deal is specifically for feature phones; Microsoft retains the rights to its operating-system powered Windows Phone devices. The company specifically mentioned it would continue to develop its WP 10 OS, and to support phones currently using the operating system which are manufactured by Microsoft and its hardware partners.
Under Nadella, Microsoft has redefined the idea of "mobile-first" by working to profit from all mobile devices, not just the units his company manufactured. Additionally, the company continues to market its Surface line of tablets and has added a two-in-one device using the Surface branding.
Nadella’s clarification of “mobile first,” combined with the writedown and the lack of new features or updates in nearly two years, point to a company looking to exit smartphone operations. Rumors as well of a Surface Phone continue to be bandied about. But even if Microsoft is able to make a high-quality Surface Phone, it's unlikely to change WP's trajectory as the smartphone market has become a mature-upgrade driven market in the high-end.
At this point it seems more likely Microsoft will exit the phone business entirely than challenge high-end device makers like Apple and Samsung.


title: Uas search and rescue symposium

text:
The first-ever symposium on the uses of autonomous robotics systems and vehicles for emergency first responders is being hosted by the University of Nevada, Reno April 6-8.
"The potential for uses of unmanned autonomous systems in emergency situations is enormous," Warren Rapp, business director of the University's Nevada Advanced Autonomous Systems Innovation Center, said. "This symposium will explore opportunities, present case studies and include panel discussions to foster dialogue on how first responders use, or would like to use, autonomous systems."
The conference will feature leaders in the fields of search and rescue, emergency management, robotics and autonomous vehicles as well as from government and non-profit institutions.
Featuring two days of seminars, the symposium also includes a social event where participants will be treated to the Aces AAA baseball team's season opener on Thursday, April 7.
Law enforcement agencies, search and rescue professionals, emergency management personnel, UAS manufacturers and researchers are all invited to attend to the event, which includes a small trade exhibit, presentations of academic research, real-world case studies and vendor talks - all designed to inform current and potential users about the latest state-of-the-art in UAS technologies and to streamline adoption of UAVs into search and rescue and emergency management.
"Because we are one of the few Universities in the country that is heavily involved in researching the benefits and capabilities of UAVs being integrated into search and rescue operations we decided it was a natural fit to host this UAV SAR Symposium," Rapp said.
Bringing together first responders, vendors and industry leaders, the symposium will foster dialogue on how first responders use or would like to use autonomous systems.
"We have a great relationship with sheriff's organizations and first responders, and they are excited for this event to take place," Rapp said. "We have a National Science Foundation grant to develop and integrate UAS platforms and systems into disaster scenarios that includes several University faculty, the Washoe County Emergency Management Office and the Washoe County Sheriff's Office."
Adapting existing UAS technologies to work in public safety offices requires understanding the specific needs and constraints of how drones and other autonomous systems could be used in emergency or public safety scenarios
Rapp said NAASIC, which supports advanced autonomous robotic systems and advanced manufacturing industries, is proud to partner with area businesses and organizations, such as the El Dorado and Silver Legacy resort casinos, Drone America and the Washoe County Sheriff's Office, for the symposium.


title: VIRGO Apartaments Mamaia - Mamaia

text:
VIRGO Apartaments Mamaia - Mamaia
Romania travel experiences: all accommodation types across Romania's most popular destinations including Bucharest, Brasov, Sighisoara, and Sibiu. Compare prices on hotels, guesthouses, apartments and luxury villas while securing the best deals for car rentals to explore the breathtaking Transfagarasan Road or the picturesque Danube Delta. Book skip-the-line tickets to Romania's iconic attractions including the mysterious Bran Castle and majestic Peles Castle. Book in Romania today, Book now!
VIRGO Apartaments Mamaia
Mamaia Bulevardul Mamaia Nr. 459 Ap. 9
Located in Mamaia, 500 metres from Mamaia Beach and 100 metres from Siutghiol Lake, VIRGO Apartaments Mamaia offers air conditioning. It is situated 5.9 km from City Park Mall and provides a lift. This pet-friendly apartment also has free WiFi.
The spacious apartment with a balcony and lake views features 1 bedroom, a living room, a flat-screen TV, an equipped kitchen with an oven and a microwave, and 1 bathroom with a hot tub. Towels and bed linen are provided in the apartment. At the apartment, there is a dressing room for guests to change in.
Ovidiu Square is 11 km from VIRGO Apartaments Mamaia, while Dobrogea Gorges is 44 km away. Mihail Kogălniceanu International Airport is 24 km from the property.
The hotel day starts from hour 14:00 and ends at 11:00.
This property willaccommodate hen, stag or similar parties.
Please inform in advance of your expected arrival time. You can use the Special Requests box when booking, or contact the property directly with the contact details provided in your confirmation.
Managed by a private host
One-Bedroom Apartment. This apartments special feature is the hot tub. This spacious apartment comprises 1 living room, 1 separate bedroom and 1 bathroom with a bath and a hairdryer. In the kitchen, guests will find a stovetop, a refrigerator, kitchenware and an oven. The air-conditioned apartment provides a flat-screen TV with cable channels, a washing machine, a tea and coffee maker, a wardrobe as well as lake views. The unit offers 3 beds.
Delivered food is securely covered
Designated smoking area
Physical distancing rules followed
Property is cleaned by professional cleaning companies
Guest accommodation sealed after cleaning
Shared stationery such as printed menus, magazines, pens, and paper removed
Facilities for disabled guests
Hand sanitizer in guest accommodation and key areas
Use of cleaning chemicals that are effective against Coronavirus
CCTV in common areas
CCTV outside property
Physical distancing in dining areas
Guests have the option to cancel any cleaning services for their accommodation during their stay
Linens, towels and laundry washed in accordance with local authority guidelines
Face masks for guests available
Staff follow all safety protocols as directed by local authorities
All plates, cutlery, glasses and other tableware have been sanitized


title: Laal singh chaddha kareena kapoor aamir khan saif ali khan kiran rao and others will be at the red carpet events before the premiere

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Aamir Khan and Kareena Kapoor Khan’s film Laal Singh Chaddha is finally going to be released today. As soon as the film’s trailer was released, it quickly became the centre of attention. The film’s makers are now holding a premiere of the film just one day before it is shown to the public. Also in Laal Singh Chaddha are Mona Singh (Mona) and Naga Chaitanya (Naga) in key roles. Saif Ali Khan, Kiran Rao, and a slew of other celebrities were spotted at the premiere, which was captured on camera.
It was the premiere of Laal Singh Chaadha.
In the photos, we can see Kareena Kapoor Khan in a white salwar-kameez. She wore a black-colored bindi and a matching jooti with her hair loosely parted. Aamir Khan wore a white tee shirt layered with a pink shirt, light blue jeans, and brown shoes, while the actress wore a white blouse. Meanwhile, Saif Ali Khan wore a blue shirt with black jeans and brown shoes to look sharp. Kira Rao wore a green and beige maxi dress with black boots and looked stunning.
Proma Khosla, writing in Indie Wire’s review, says: “Instead of the obvious Indian equivalent or a box of chocolates, the film takes things a step further, adding strong depth and resonance to what could otherwise have been an unremarkable adaptation.” Adding to that, “Laal Singh Chaddha measures its emotional beats tactically, deploying poignant punches sporadically throughout,” she said. As Fred Topel of United Press International noted in his review, “Laal Singh Chaddha is faithful to Forrest Gump, from the floating feather to the plot structure. There’s a greater emphasis on the story itself because history isn’t as crucial to the plot.
The name of Laal Singh Chaddha.
On the other hand, Laal Singh Chaddha, Aamir Khan, and Kareena Kapoor Khan’s upcoming film, is scheduled to be released on August 11. The popular Hollywood film The Forrest Gump, starring Tom Hanks and Laal Singh Chaddha, has now been officially translated into Hindi. Aamir is bringing the film, which was a critical and popular success, to the Hindi-speaking film industry. Naga Chaitanya, a popular name in the South, will make his Bollywood debut in this film. The film will go up against Raksha Bandhan, which stars Akshay Kumar and Bhumi Pednekar, at the box office.


title: L5m3 new questions

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Restitution Measures are an award which seeks to return the value of a benefit which has been seen to be unfairly received. Which of the following statements about Restitution Measures is TRUE? Select TWO
An exchange of written documents between a buyer and supplier, each detailing their own Terms and Conditions is known as the Battle of the Forms. Who generally wins the Battle?
Franky B's is a popular restaurant chain which is seeking a resolution to a conflict it has with its supplier of Fried Chicken. It is looking for a dispute resolution that does not involve the court but in which an expert third party will make a binding decision. Which is the most suitable dispute resolution method for Franky B's?
Buyer A and Supplier B have had a disagreement regarding a breach in the contract. They are looking to resolve the issue via arbitration. Which of the following is true about arbitration?
A failure to perform a provision of a contract which does not affect the end performance of the contract is known as what?
Tyrone Enterprises has just come out of a meeting with one of its suppliers Bob. The meeting has not gone well and the contract has become frustrated. What does this mean?
Tutu Incorporated has a contract with a software company to provide their IT software. They want to ensure that the supplier pays compensation if there are any issues with service (e.g. the software doesn't work for a day). Which two items would Tutu Incorporated need to include in the contract?
A contract term which is difficult to classify at the time of drafting a contract is known as?
Sarah is a baker and orders free-range eggs from a local supplier which she uses to make cakes. There is a contract in place which included a specification that states that the eggs must be free-range. One day the supplier delivers eggs which Sarah uses in the cakes. Later she dis-covered that these were not free-range. Sarah believes that the supplier has broken the con-tract. Is this true?
John has signed a document with Larry that says that he will give Larry his car. Both John and Larry are over the age of 18 and are of sound mind. Larry accepts this offer and signs the document. Is this a contract?
Harry is negotiating a contract for a new IT system for his business. He is investing heavily in the system and wants the system to be able to provide the services he requires for the next 10 years. However he is aware that technology is changing quickly and would like to include a clause in the contract to ensure that the system he is purchasing is useable for the next 10 years. What should Harry include in the contract?


title: Collagen services

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Collagen serves as an essential structural protein that finds application in numerous fields such as pharmaceuticals, cosmetics, and biomedical sectors. BOC Sciences provides complete collagen services because of its essential role in connective tissue and diverse applications throughout preparation, modification, formulation, and testing. We customize our services to address the specific requirements of each client whether they need laboratory research facilities or large-scale production capabilities.
Collagen functions as a critical structural protein present in connective tissues throughout the body which are found in skin, bones, tendons, cartilage, and blood vessels. Collagen functions as the body's architectural framework by providing tissues with their necessary strength and flexibility along with structural support. The triple-helix structure of collagen consists of amino acids including primarily glycine and proline alongside hydroxyproline. Collagen represents the most abundant protein in mammals and makes up approximately 30% of the total protein content in the human body. Type I collagen represents the most prevalent type found across various tissues including skin and tendons as well as bones.
Our collagen production process combines enzymatic hydrolysis with membrane filtration to maintain both bioactivity and superior mechanical properties.
Our specialized collagen products feature molecular weights adapted to distinct applications including low molecular weight collagen peptides for quick absorption and native collagen suitable for use in tissue engineering.
Through chemical cross-linking and peptide conjugation, our collagen modification services enable exact control of collagen properties including stability, solubility, and mechanical strength.
Our recombinant collagen production process generates high-purity products free of animal-derived contaminants which results in safer and more reliable outcomes for pharmaceutical applications and medical uses.
BOC Sciences offers a wide range of collagen products, including native collagen for tissue engineering and wound healing, hydrolyzed collagen for use in nutritional supplements and cosmetics, and recombinant collagen for high-purity biomedical applications. Our product portfolio also includes crosslinked collagen, collagen peptides, and various derivatives, all designed to meet the specific requirements of diverse applications in both medical and cosmetic fields.
We extract high-purity collagen from bovine, marine, or recombinant sources via enzymatic hydrolysis and advanced purification. Services include molecular weight fractionation, endotoxin removal, and sterilization for biomedical, cosmetic, and tissue engineering applications.
Customize collagen via crosslinking (UV/enzymatic), PEGylation, or glycosylation to enhance stability, solubility, or targeting. Applications range from pH-responsive drug carriers to anti-aging serums with improved penetration and immunologically inert scaffolds.
Develop collagen-based gels, emulsions, or microneedle systems tailored for skincare or medical use. Optimize viscosity, degradation rates, and compatibility with actives like hyaluronic acid or growth factors for enhanced efficacy.
Design injectable collagen fillers for facial volumizing, lip augmentation, or scar revision. Adjust crosslinking density for longevity (6-24 months) and integrate pain-reducing agents for seamless blending with natural tissues.
Perform assays for purity (SDS-PAGE), molecular weight (SEC-MALS), endotoxin levels, and microbial contamination. Validate triple-helix integrity via CD spectroscopy to ensure bioactivity and structural consistency.
Evaluate biocompatibility, degradation kinetics, and collagen regeneration using 3D skin models, murine wound healing assays, or dermal safety studies. Generate data to support functional claims and safety profiles.
Engineer nano-collagen (<200 nm) via electrospinning, nanoprecipitation, or microfluidics. Applications include targeted acne therapy, antioxidant serums, and bio-inks for 3D-printed skin constructs with enhanced precision.
BOC Sciences provides a range of advanced collagen formulation technologies to cater to diverse customer needs and industry applications. Our collagen production technologies primarily include animal tissue extraction and recombinant DNA technology, each offering unique advantages, enabling us to deliver tailored solutions to meet specific application and product requirements.
BOC Sciences has extensive expertise in collagen extraction from animal tissues, particularly from bovine, porcine, and marine sources. Using advanced enzymatic hydrolysis, separation, and purification techniques, we maximize the preservation of collagen’s structural integrity and bioactivity. These methods ensure a high-quality product with a consistent molecular weight and desirable properties suitable for a wide range of cosmetic, pharmaceutical, and biomedical applications.
BOC Sciences employs recombinant DNA technology to produce collagen in engineered microorganisms, offering a sustainable and scalable production method. By optimizing microbial strains such as Escherichia coli and Saccharomyces cerevisiae, we ensure high-yield production of collagen peptides with precise control over molecular size and sequence. This technology offers a more ethical alternative by reducing reliance on animal-derived materials and ensuring consistent quality.
BOC Sciences also offers customized collagen formulation services, allowing us to adjust collagen properties such as molecular weight, crosslinking degree, and amino acid composition to meet specific functional and performance needs. Additionally, we can create collagen derivatives with specialized features for unique applications, such as collagen-based drug delivery systems, wound healing, and anti-aging products.
BOC Sciences boasts robust large-scale manufacturing capabilities for collagen production, adhering strictly to GMP certification standards to ensure the highest quality and safety across all stages of production. We offer collagen production from laboratory-scale to industrial-scale, providing flexible supply options ranging from gram to kilogram and ton-level quantities, tailored to meet customer demands. As a GMP-certified manufacturer, BOC Sciences rigorously follows international quality management standards throughout the entire production process, including raw material procurement, manufacturing, quality testing, and packaging. Our state-of-the-art facilities and advanced production equipment enable us to maintain highly standardized workflows, ensuring consistent quality for every batch of collagen products.
BOC Sciences provides advanced collagen purification solutions using techniques such as ultrafiltration, ion exchange, gel filtration, and membrane separation. These methods effectively remove impurities, endotoxins, and other contaminants, ensuring the final collagen product is biocompatible and safe for a wide range of applications. Whether intended for pharmaceutical, cosmetic, or biomedical use, our collagen purification services deliver products of exceptional quality. Furthermore, BOC Sciences maintains a robust analytical testing and quality control system, ensuring each batch of collagen meets rigorous standards for consistency and safety, offering reliable solutions for our customers.
BOC Sciences utilizes a comprehensive suite of advanced analytical techniques to ensure the highest quality of collagen products:
BOC Sciences offers comprehensive quality testing services for collagen products to ensure optimal performance and safety:
Collagen, with its excellent physical and chemical properties and biological functions, has a wide range of applications across various fields, including medical, cosmetic, food, and industrial sectors. Its role in tissue engineering, drug delivery, wound healing, anti-aging treatments, and environmental material development is particularly significant.
BOC Sciences offers collagen purification, modification, custom synthesis, and application solutions for various industries, including pharmaceuticals, cosmetics, and biomedical fields, supporting both R&D and full-scale production.
Type I collagen is widely used in medical applications, such as wound healing, tissue engineering, and orthopedics, due to its abundance in the body and excellent biocompatibility.
Collagen promotes tissue regeneration by providing structural support, encouraging cell proliferation, and accelerating the healing process, particularly in burn treatments, surgical wounds, and chronic wounds.
Collagen improves skin elasticity, reduces wrinkles, and restores volume, making it a key ingredient in anti-aging treatments like dermal fillers and collagen injections for facial rejuvenation.
Collagen supports joint health by enhancing cartilage regeneration, reducing pain, and improving mobility. It is commonly used in supplements for osteoarthritis and joint pain management.
Collagen in cosmetics boosts skin hydration, elasticity, and firmness, helping to maintain youthful, smooth skin. It is often used in face creams, serums, and anti-aging products.


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What Entails in AS400 System Documentation?
System documentation consists of minute details of AS400, leading to an organized way of managing and understanding the system as well as monitoring the overall health of the system. Here are some of the fundamentals of a good AS400 documentation:
1) General System Documentation
This consists of comprehensive documentation of iSeries system hardware, configurations, server models and operating systems which are being used.
This documentation is crucial for disaster recovery and technology upgrades, as it provides a concise overview of the system’s architecture and specifications.
2) DevOps Documentation
Besides infrastructure, documentation needs to span process and workflows to integrate IT operations with development teams.
This requires logging code modifications, version control systems, user roles and responsibilities, network configurations, and deployment methodologies (like A/B tests and shadow deployments).
3) Process Documentation
Process-related documentation outlines task flows, system manuals, workflow navigation, and user journey mappings.
Training new users, staff, and teams to maintain consistent operational processes is vital, and these records are indispensable in achieving that objective.
4) Integration Documentation
Documenting integrations is essential for modern AS400 systems due to their complexity. Information such as custom adapters, integration standards, and types of integrations used (like EDI, APIs, Webhooks) is included.
These records facilitate troubleshooting further supporting interoperability with other systems.
Why Companies Struggle with AS400 System Documentation?
Documenting AS400 systems is an extremely important task that many enterprises neglect. Although AS400 documentation is essential, several challenges can prevent organizations from starting or continuing proper AS400 documentation.
a) Dwindling Expertise
The AS400 solution has been around for decades and is typically run by seasoned RPG programmers and IT professionals who are approaching retirement.
Adding to the problem is a lack of new talent pipeline to replace them, as modern developers are not familiar with the system which further deepens the issue
This declining pool of resources forces enterprises to depend on a narrowing group of specialists, frequently relegating documentation activities to a lower priority.
b) Perceived Lack of Urgency
AS400 systems have existed for so long, that most existing AS400 teams know their way around quite well.
However, this reliance on the expertise of a few creates a false sense of security that often leads businesses to skip the documentation process, under the impression that it is not required, until critical knowledge gaps become apparent.
c) High Cost and Effort
AS400 System documentation requires dedicating time, effort, and financial resources to setup; not to mention the ongoing maintenance costs.
Organizations consider this a low-return activity that pales in comparison with their other IT efforts, so documentation is often delayed or deprioritized.
d) Resource Constraints
AS400 systems often weigh heavily on IT teams for resolving system issues or handling requests from users. As their bandwidth is occupied managing day-to-day operations, documentation is pushed to the backburner and leaves enterprises with incomplete or outdated records.
e) Growing Complexity of Legacy Systems
AS400 systems have often been developed and refined over decades, rife with customizations and integrations, making documentation a labour-intensive effort.
Getting a grip of the system’s architecture for newer members of a team becomes nearly impossible when no proper records exist.
Recommended Read: Everything You Need To Know About AS/400 iSeries (IBMi)
The Importance of Documenting the AS400 System
AS400 systems documentation is a key practice that ensures operational continuity, eases the troubleshooting process, and protects against future uncertainty.
The AS400 is a robust legacy system used in many companies. However, due to its long history and complexity, a well-tended documentation is required. Here are the key benefits:
a) Facilitates Faster Resolutions
When something goes wrong, complete system documentation allows for faster troubleshooting and resolution of issues. This provides granular details about integrations, how the code is functioning and what the network looks like.
This information allows developers and IT teams to quickly troubleshoot issues. Not only does this improve performance, but it also minimizes downtime and maintains business continuity.
b) Eases Technology and Data Migration
AS400 documentation becomes crucial when systems are required to be modernized or migrated. Migrating to modern systems or the cloud often involves complex integration and data transformation processes.
The risks, issues, and costs of such transitions can be minimized and streamlined with properly documented system details, including configurations and dependencies.
c) Supports Disaster Recovery
Complete AS400 documentation is a must for recovery in case of IT disaster. Legacy developers age out and modern developers may be less familiar with iSeries technology, which will make clear documentation critical to assure that disaster recovery plans will be implemented as needed.
This reduces downtime and safeguards key business functions in the event of a disaster.
d) Simplifies Staff Training
With the retirement of AS400 developers, new hires find it challenging to work with the system’s outdated architecture. Well-structured documentation acts as an internal training manual, reducing the learning curve for modern developers.
It serves as a guide to help ensure teams can quickly adapt to new technologies and maintain, manage and operate the system when expertise is lost over generations.
e) Enhances System Stability and Security
Detailed documentation is another contributing factor to AS400’s stellar reputation which is known for stability and security. It makes sure that the updates, maintenance, and enhancements done are right without affecting the system integrity.
This documentation helps teams understand the object-based design and single-level storage, which aid in implementing security measures.
f) Lowers Cost of Ownership
The low operational cost is one of the features that the AS400 offers, but bad documentation can make those savings end up in draining time through inefficiencies in troubleshooting or migrations.
This helps business avoid unnecessary costs related to system downtime, misconfigurations, or redundant efforts.
g) Ensures Flexibility and Scalability
Well-maintained documentation supports AS400’s adaptability, allowing hardware or software upgrades to be carried out without impacting other areas. Being able to adapt is critical for organizations that intend to grow processes without losing efficiencies.
Recommended Read: How to Transform AS400 Green Screen
Challenges That Arise Without AS400 System Documentation
Failing to create comprehensive AS400 system documentation has implications that will impact not only immediate functionality, but long-term growth as well. Below are the key challenges organizations face:
a) Training Inefficiencies
Without documentation, it takes a long time to train new programmers on the AS400 system. Without clear records, onboarding processes rely on scarce in-house expertise, causing challenges in familiarizing new hires with the technical and functional workflows of the system.
b) Limited Understanding of System Functionalities
Without the documentation, non-technical employees who interact with the IBM iSeries on a day-to-day basis often fail to get a grasp of how the system operates fully.
Given this knowledge gap, informal training and trial-and-error methods only make the risk of operational disruptions more prevalent.
c) Extended Query-Resolution Times
Without a reference that maps how the system is structured and what the system can do, requests from users must be researched ad hoc, making it a tedious process.
IT teams have an increased investigation time into a myriad of unknowns before a solution is reached, resulting in slower response times and lower productivity.
d) Hindered Modernization and Migration Efforts
The architecture of the system needs to be well understood for modernization or migration initiatives. The lack of documentation, makes assessing the current setup almost impossible, leading to major hindrances in adopting technology trends or going for competitive upgrades.
e) Strategic Growth Limitations
Lack of documentation limits the scope of strategic planning. CIOs and decisionmakers will not have the visibility required to understand the capabilities of the system and take informed decisions to scale or innovate, hindering opportunities for long-term growth.
Creating AS400 system documentation is a multi-faceted effort which requires convergence of technical information, operational workflows, and integration details.
The combination of resource scarcity, cost concerns and operational pressure leaves companies unable to document their AS400 systems.
However, when left unaddressed, these challenges can eventually lead to long-term inefficiencies, knowledge silos, and higher risks around transitions, management and emergencies.
Having detailed and up-to-date documentation can help organizations increase system reliability, streamline training, and plan for future upgrades or transitions.


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Everything you need to know about knee pain
Our knee is the most complicated and largest joint in our body. It’s also the most vulnerable because it bears enormous weight and pressure loads while providing flexible movement. When we walk, our knees support 1.5 times our body weight; climbing stairs is about 3-4 times our body weight and squatting about 8 times. Because of the complexity of the muscles and tendons and ligaments around this joint, it is common for it to become sore after overuse or strain.
Severe knee pain that is caused by overuse typically subsides on its own after a few days, but you can try a few of these home care techniques to help reduce the pain while you heal:
Icing — Apply a bag of ice or frozen vegetables to the sore area for 15 minutes two or three times a day. Do this for a few days to help reduce the swelling and assist with managing pain.
Heating –After a couple of days of icing, you can begin to apply some heat. Heating the sensitive area should help provide some comfort while you’re recovering. Do not heat immediately when you initially experience pain because heating can make inflammation worse.
Resting — Cut back on physical activities that put a lot of stress on your knee. You should continue maintaining some level of activity, but do not overdo it and cause more pain to develop in your knee.
Compressing — To help reduce swelling, you should wrap your knee in a compression bandage. Do not wrap the knee too tight or you may cut off circulation or cause pain to grow more severe.
This kind of treatment should help provide some relief while your knee heals, but if your knee pain is more extreme or long-lasting, you should seek medical attention.
Treatment of knee pain depends entirely on the cause of the problem.Therefore, it is of utmost importance that you understand the cause of your symptoms before embarking on a treatment program. If you are unsure of your diagnosis, or the severity of your condition, you should seek medical advice before beginning any treatment plan.
Getting help for severe knee pain
At Health Plus Physical Therapy, our physical therapists can identify the cause of your knee pain and assist you one on one physical therapy treatment to help you recover.
Some of the most common causes of severe knee pain include:
Ligament and meniscus tears
Tendinitis and more
Health Plus Physical Therapy team that has years of experience in working with a variety of musculoskeletal conditions like severe knee pain.
Get in touch or speak with the team at Health Plus Physical Therapy& Rehabilitation Center, Edison about your knee pain? Contact Us today to schedule an appointment to live pain free life.


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Thursday, January 3, 2013 - Article by: Barb Lanis - The Federal Savings Bank is a member FDIC and Equal Housing Lender -
Why won't my Lender do a HARP refinance with LPMI?
The 2012 revised HARP refinance program (which we in the mortgage business affectionately call HARP 2.0), brought many positive enhancements for borrowers. Initially, the HARP program had limitations and left many borrowers out in the cold with no way to refinance.
Overall, it was a great program, but it became clear that further efforts needed to be made to enhance the program to include more borrowers.
The enhancements with HARP 2.0 as it relates to BPMI/LPMI are very straightforward:
Borrowers who currently have BPMI or LPMI can now refinance and have their mortgage insurance certificate transferred to their new loan - at the same premium rate of their previous loan.
Why won't my Lender do this type of HARP Refinance?
Although Fannie/Freddie now allows HARP refinances with BPMI and LPMI, there are many lenders that have made the business decision that they will not do them. Perhaps it's that tiny extra step to have the MI Certificate transferred to the new loan. Keep in mind that even though Fannie/Freddie allow for certain types of loans to qualify for HARP, it does not mean that they can compel lenders to do them.
What To Do and What You Need To Know if your Lender/Servicer will not refinance a loan with BPMI or LPMI
If you currently have BPMI, then the monthly premium amount will be the same as it was with the old loan. This is a good thing because current MI premiums are much higher than those from 5-6 ago!
If you currently have LPMI, the MI Certificate is simply transferred as it had already been paid in full with your last loan.
If you have the variation where you have LPMI, but your Lender/Servicer is paying it monthly on your behalf, you will now a have monthly mortgage insurance premium included in your payment. Again, it will be at the old (and lower) premium that you originally had. Generally, the amount is so minimal that it pales in comparison to the savings obtained by dropping the interest rate.
Reminder, make certain that you tell your Loan Officer up front that you have, or think you have, BPMI or LPMI on your current loan.
Didn't find the answer you wanted? Ask one of your own.


title: Artwork science digital experience design

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Concordia University Chicago’s College of Arts and Sciences gives a standard curriculum including studies within the humanitieshttps://www.vamvision.com communicationhttps://www.vamvision.com literaturehttps://www.vamvision.com social and behavioral scienceshttps://www.vamvision.com natural scienceshttps://www.vamvision.com mathematics and theology. As a part of the Illuminating Requirements Challengehttps://www.vamvision.com Harvard graduate college students have been invited to provide short films that present what a detailed take a look at student work reveals and illuminates about Common Core and different requirementshttps://www.vamvision.com just like the Next Generation Science Standards.
The planned artwork & science programhttps://www.vamvision.com including two creative residencies at analysis instituteshttps://www.vamvision.com intention to link up scientific aspects and ideas with approaches utilized in digital artworkhttps://www.vamvision.com fostering interdisciplinary work in direction of intercultural and inter-milieus exchange.
ASN will present several artistic projects making res invisible seenhttps://www.vamvision.com during which mobile robots turn into not only metaphors of life and its evolutionhttps://www.vamvision.com of magnificence and fact in naturehttps://www.vamvision.com but in addition technique of interpersonal communication and embodiment of human pridehttps://www.vamvision.com creativityhttps://www.vamvision.com desires as well as fears.
The integrated set of required programshttps://www.vamvision.com provided solely to Arts & Science college studentshttps://www.vamvision.com embrace Inquiry courseshttps://www.vamvision.com which cover a range of disciplines and deal with the development of drawback-primarily based learning and significant pondering abilities.
A Publish-Graduate Certificates Course in Human-Centered Economics might be performed by the World Academy of Artwork & Sciencehttps://www.vamvision.com the World College Consortiumhttps://www.vamvision.com The Mom’s Service Societyhttps://www.vamvision.com Person-Centered Approach Institutehttps://www.vamvision.com Dag Hammarskjöld University College of Worldwide Relations and Diplomacy and Inter-College Centrehttps://www.vamvision.com Dubrovnikhttps://www.vamvision.com Croatia from Feb 1-Feb 3https://www.vamvision.com2017 at Inter-University Centrehttps://www.vamvision.com Dubrovnikhttps://www.vamvision.com Croatia.


title: Zebra accent chair

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4th of July Sales Event | Going on Now | See All Offers4th of July Mattress Sale | Shop NowSave $100 when you combine any Sofa & Wall Art± | Use Code: SW1Get $175 off when you combine any Bed & Mattress† | Use Code: BM7Save $100 when you combine any Dining Table & Wall Art± | Use Code: DNW
29.5" W x 32.5" D x 32" H 75 cm W x 83 cm D x 82 cm H
Antique Brass Accents
Make a bold statement in your space with the stunning Zebra Accent Chair. Made with microsuede fabric and leatherette, this zebra print occasional chair features antique brass accents, a lovely two-tone contrast, and welt-trim. Its transitional style and eye-catching appeal make it the perfect choice to add a splash of sophistication to any room.
Assembly Difficulty Level: No Assembly: Simply take the merchandise out of their packaging. No assembly required.
Heavy: Keep in mind that this merchandise is heavy.
Care: When you purchase upholstered furniture, you want to make sure it lasts a long time in your home for you to enjoy for years to come. In order to keep your pieces strong and prevent soiling, it is best to take care of your fabric with routine maintenance such as lightly brushing the fabric with a soft brush or vacuum. This helps remove the accumulation of dust and grime.
Sometimes life is not under our control. If you encounter a spill on upholstered furniture, do not leave it untreated for too long or else it will be absorbed into the fabric of the piece and will be harder to remove. Make sure the area is completely dry once you are done cleaning it.
Please keep in mind that the use of a professional cleaning service is always recommended if you do not feel comfortable cleaning an upholstered piece yourself.Warranty Information
On Display at Your Local Store
El Dorado Furniture - Fort Myers Boulevard
4429 Cleveland Ave Fort Myers, FL 33901(239) 938-3400


title: Release Date: August 17th 2018

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Release Date: August 17th 2018
Reviewed by: Joshua Andre
So here we are, in December. You know what the time is now? Yes, seriously, another post about my favourite EPs that have been within the months of July – December 2017. I can remember back in July when I compiled my favourite EPs from January – June, and now, I have 15 more EPs that have spoken into my life since then. So, I guess when I look at the year as a whole, I can safely say that 2017 is the year of the EP. I’m sure if you take a look at my favourite 30 (15 for the first half and 15 for the latter half) EPs this year, I’m sure you can tend to agree. Anyway, enough preamble. Here’s my top 15 EPs of the last half of the year, that have made a great impact on myself both spiritually as well as enjoyableness.
Hello again! Two times in one day, isn’t this a treat! If you’ve read my previous best of 2017 post, then you’ll know I delved into my favourite 20 songs released from July – September 2017. So what else could I post about, given the posts we’ve already written about in the ‘Best of 2017’ series? Well, it’s time to speak about 10 releases that are most anticipated (by myself!) that are set to release within the next three months. Though the year’s gone by and there are thousands of releases that have been unveiled in 2017, let us remember that there are 90 odd days remaining in the year for us to be blessed with new music and up and coming artists. So let us without further ado delve into 10 albums releasing in the last quarter of 2017 that we are excited about!
It’s that time of the year again. The end of September/beginning of October means that we’re due to post another best of 2017 list! Excited? This time, it’s time to reveal our favourite songs from July – September 2017. You can check out our previous ‘best of 2017 song lists’ here (Jan-March 2017) and here (April-June 2017), and be sure to let us know your thoughts on your favourite songs!
Just a few months ago, I posted my favourite songs of 2017 thus far, from January – March 2017. Now here is a follow-up post, favourite songs from April – June 2017. And while this type of series hasn’t really been done before (in previous years, I’ve only posted one ‘top songs of ____’ post at the end of that particular year), I’ve said, and I will say again, that 2017 is the year of the song. Not just hit songs on albums, but just hit songs period- whether it’s on an album or just released as a single. Because frankly these days, when I look at the year up until now objectively, I have realised that more often now than years previously, artists are releasing singles as opposed to new albums. Don’t get me wrong, the number of albums this year is just as much, if not more than last year. It’s just that within these last few months, we have been blessed with tracks that aren’t necessarily attached to any album. And maybe that’s a good thing. To not have to wait until an artist as a collection of songs that they can release to listeners. Often if that is the case, artists may have to wait for management approval, or they’ll have to discuss about radio format and marketability before they release an album. In 2017, with artists releasing more songs as opposed to albums, we are ever reminded that in such an industry like the music industry, it takes a lot for an album or even a song to be released on iTunes- so we ought to be appreciative when an artist does release something, be it an album or a single.


title: Bronco billy humphrey gone from tyc

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Let me be the first to issue a hardy "Yee-Haw!" This is a fellow whose open defiance of agency rules and a Travis County district court perhaps did more to discredit new TYC management than any other person. Reported the Dallas News ("Texas Youth Commission Executive Billy Humphrey Abruptly Quits," Jan. 10):
This easily constitutes the most positive move so far by TYC's new conservator. Hopefully it's a harbinger of even more significant change to come.Mr. Humphrey’s departure was initiated by new TYC conservator Richard Nedelkoff, who was appointed by Gov. Rick Perry in December.
“This was a decision that the new conservator came to after his overview looking into agency operations and management personnel,” said Mr. Hurley.
Mr. Humphrey couldn’t immediately be reached for comment. A person who answered the phone in Mr. Humphrey’s TYC office said: “I can’t give you any information at all, sir.”
Mr. Humphrey, 39, an 18-year veteran of the state’s adult prison system, was hired by Ms. Pope last summer to help reform the troubled agency. As deputy director of residential services, responsible for all TYC institutions, halfway houses and contract-care facilities, he quickly clashed with TYC administrators over his efforts to expand the use of pepper spray and solitary confinement as ways of controlling unruly inmates.
Ms. Pope and Mr. Humphrey have defended the efforts to expand the use of pepper spray against inmates as a means of reducing injuries to TYC staff and inmates.
Within weeks of his hiring, Mr. Humphrey clashed with TYC administrators as he imposed policies that expanded the use of pepper spray and segregation of disruptive inmates, according to Teresa Stroud, superintendent at TYC’s Brownwood juvenile prison, and Jeffrey Berry, an assistant superintendent at the Mart juvenile prison until Mr. Humphrey transferred him to a TYC facility in Vernon - 270 miles away - in October.
“Administrators want to avoid conflict and interaction with Mr. Humphrey for fear he will move them to a remote location and displace their entire family," Ms. Stroud alleged Oct. 11 in her written grievance.
“Administrators are now tendering resignations, avoiding applying for promotions and asking for voluntary demotions just to avoid direct contact with him so they protect their livelihoods and keep their families intact,” she wrote.
MORE: From the Austin Statesman,


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Published: 14.09.2019 by Moritz Scholjegerdes
The FVA-30 is designed as a hybrid-electric powered glider for medium-range flights (600-800 km), with the range extender (REX) providing the power required in cruise flight (optimum operating point). The battery is used here to cover power peaks in the flight profile (takeoff, climb, possibly through takeoff maneuvers) and buffer power fluctuations in cruise flight. In the first expansion phase, however, the certification of an all-electric prototype is initially planned, which will allow autonomous takeoff, climbing to 1000 m altitude (above ground) and a 15-minute cruise flight under pessimistic conditions.
Realization phase I: Battery-electric prototype
For the battery-electric prototype, we will initially use the simplest possible system architecture and then systematically increase the complexity with time and experience. For this purpose, we will firmly connect each inverter to a battery and thus leave the drives of the left and right side completely separated from each other (see figure below). Furthermore we want to do without an additional control to the one in the inverters in the beginning by controlling the inverters directly and only via the thrust levers. The control unit in the cockpit should only serve to display information and not be relevant to the system. However, due to the separation of the drive trains, one isolation monitor per battery is required compared to the Phase II system plan (see next section). The DC-DC converter between HV and LV level is to be omitted in the first expansion stage of the FVA-30 and replaced by a larger low-voltage battery, which is why each drive side is to get its own 12 V LiFePo battery.
System plan of the drive train of the battery-electric prototype (phase I)
The planned redundancy in the powertrain is also reflected by the division of the battery system into two independent parallel battery systems, each with its own BMS. The coupling of the two HV-DC strings planned in the second expansion phase thus allows both motors to be operated in the event of a one-sided battery failure (see battery tests, redundancy case).
Realization phase II: Hybrid-electric operation
In hybrid-electric operation, the range extender feeds the power required for cruise flight via an AC/DC converter into the DC link, whose voltage is regulated to the battery voltage in pure REX operation. The powertrains coupled via the power distribution unit are additionally connected via a DC/DC converter to the 12 V on-board power system to supply the on-board electronics and avionics, so that the latter only has to fall back on the downsized backup LV battery in an emergency. An insulation monitor is used to monitor the insulation status of the two HV batteries.
Rough system plan for hybrid-electric operation (phase II)
Outlook: A detailed system plan is currently being developed, including signal flows and control electronics.


title: Messenger30 readme sp1

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The information in this Readme file pertains to Novell Messenger 3 Support Pack 1.
Novell Messenger 3 Support Pack 1 offers enhanced functionality over prior Messenger versions:
SSL Connection Requirements: Messenger now requires all communications except those to eDirectory to be secure. You can either use a publicly signed cert or Messenger will create the server certificate during the installation. For more information about using certificates in Messenger, see Messenger System Security in the Novell Messenger 3.0 Installation Guide.
PIN Support for iOS and Andriod Apps: The Messenger app can now be locked with a PIN so only you can access it. Along with using the PIN, you can also used iOS TouchID to unlock the app. For more information, see Turning on the Passcode in the Novell Messenger 3 Service Pack 1 Mobile Quick Start.
Custom Status Support for iOS and Andriod Apps: You can now edit and create custom status’ inside the apps. For more information, see Creating a Custom Status in the Novell Messenger 3 Service Pack 1 Mobile Quick Start.
Novell Messenger 3.0 system requirements (including requirements for mobile devices) are listed in in the Novell Messenger 3.0 Installation Guide.
Complete installation instructions are available in the Novell Messenger 3.0 Installation Guide.
In some cases, the Messaging Agent does not start automatically even when the startup type has been set to Automatic, as described in in the Novell Messenger 3.0 Installation Guide.
To work around this issue:
On the Windows server where the Messaging Agent is running, launch the Run application.
Type services.msc, then press Enter.
Right-click Novell Messenger Messaging Agent, then click Properties.
On the Recovery tab, in the First failure drop-down list, select Restart the Service.
In the Second failure drop-down list, select Restart the Service.
You cannot search the Messenger Archive for conversations based on a user if that user resides in an eDirectory OU that contains the & (and) character.
When running Messenger on SLES 12, ConsoleOne fails to start because the following dependency is missing:
Install the libXtst6 package, then proceed to run Messenger.
When installing Messenger, the installation location where you plan to install Messenger cannot contain extended or double-byte characters.
When installing Messenger with eDirectory 8.8.5 with LDAP mode on Linux, you must manually extend the eDirectory schema.
How you extend the schema depends on whether eDirectory is installed locally or remotely.
When running Messenger on SUSE Linux Enterprise Server (SLES) 11, you need to install the libstc++.so.5 or greater library.
If you try to connect to eDirectory 8.8 from Novell Messenger with a case-sensitive password, eDirectory 8.8 might not recognize the case-sensitive password. For information on how to enable case-sensitive passwords in eDirectory 8.8, see “How to Make Your Password Case-Sensitive” in the eDirectory 8.8 What’s New Guide.
If you are storing any encrypted Novell Messenger attributes in eDirectory 8.8, you cannot see these attributes in ConsoleOne until they are unencrypted.
The Messenger install/upgrade now requires Security settings (SSL certificate and key) to be written to the Server object. If you have overwritten these settings on the Agent objects, the Security settings that are set during the install/upgrade will not apply to the Agents. If you want the Server object Security settings to apply to the Agents, go to the Agent object > Security in ConsoleOne and click Reset to Defaults.
Messenger does not support storing the history files from multiple clients in a shared Filr storage location. Because Messenger supports simultaneous client connections, storing history information to a single Filr location for multiple clients can result in corrupt history files.
When creating a chat room, changing the owner to someone other than yourself before the chat room is created results in an error message. The chat room is ultimately created, but not all configuration changes are saved. The new owner must then edit the chat room and make the equivalent changes.
The iOS app and the Android/Blackberry app use different methods to connect to the Messenger server.
The Android/Blackberry app behaves the same way as the desktop clients. It uses a direct internet connection to the server and is in constant contact with the server. If the app cannot connect to the server, it attempts to reconnect in the background. After it reconnects to the server, it pulls down any queued messages.
The Messenger server uses Novell Push Notification Service, which uses Apple Push Notification, to push messages to the iOS app. This does not require the app to have constant communication with the Messenger server. If the iOS app is not used for 24 hours, it times out and you are logged out by the server. You then receive a notification that you have been logged out. If you were only logged into Messenger through the iOS app, you appear offline to others users in the system. To go online and receive messages again, simply open the app and login.
IMPORTANT:The third-party messenger systems discussed in this section do not support the simultaneous client connections available with Messenger 3.0.
The Adium instant messaging application for Mac OS X is available at the Adium website.
The Pidgin (formerly Gaim) open source instant messaging connector is available at the Pidgin website.
The Kopete open source instant messaging plug-in is available at the Kopete website.
The following sources provide information about Novell Messenger 3.0:
Online product documentation: Novell Messenger 3.0 Documentation website .
Product documentation included within Novell Messenger:
Help System: Click the Help menu in the upper-right corner of the Messenger client.
Novell, Inc. makes no representations or warranties with respect to the contents or use of this documentation, and specifically disclaims any express or implied warranties of merchantability or fitness for any particular purpose. Further, Novell, Inc. reserves the right to revise this publication and to make changes to its content, at any time, without obligation to notify any person or entity of such revisions or changes.
Further, Novell, Inc. makes no representations or warranties with respect to any software, and specifically disclaims any express or implied warranties of merchantability or fitness for any particular purpose. Further, Novell, Inc. reserves the right to make changes to any and all parts of Novell software, at any time, without any obligation to notify any person or entity of such changes.
Any products or technical information provided under this Agreement may be subject to U.S. export controls and the trade laws of other countries. You agree to comply with all export control regulations and to obtain any required licenses or classification to export, re-export or import deliverables. You agree not to export or re-export to entities on the current U.S. export exclusion lists or to any embargoed or terrorist countries as specified in the U.S. export laws. You agree to not use deliverables for prohibited nuclear, missile, or chemical biological weaponry end uses. See the Novell International Trade Services website for more information on exporting Novell software. Novell assumes no responsibility for your failure to obtain any necessary export approvals.
For Novell trademarks, see the Novell Trademark and Service Mark list.
All third-party trademarks are the property of their respective owners.


title: Burn flight team chief discusses mission care at usaisr burn center

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Given that, Williams said that this is a good time to remind service members to keep safety in mind when using items like space heaters, grills, and propane tanks, as well as around fires.
"Pay attention to those holiday safety briefs because there actually is truth to them," said Williams.
Another element of what USAISR does is research, which is guided by what an individual is interested in. Williams said she appreciates the freedom and opportunities to collaborate with her colleagues.
"What's nice about the research we do here is that you can find something you like and design a research project around it or find someone who is already doing it and join in with them," said Williams. "Everybody is very collaborative. If you can't find a project, you can just send an email out or talk to someone about what you're interested in, and they'll likely know someone who is working on it."
Williams is working on developing an application to help train medical personnel who are going downrange in estimating the severity of burns.
"If you don't see burns all of the time, there's a tendency to over- or underestimate how severe they are," said Williams.
The app will use photos and charts to help medical personnel better estimate a burn's severity.
Although part of the Military Health System, USAISR sees a preponderance of civilian patients.
"Being able to take care of civilians is what keeps our clinical readiness up," said Williams. "The burn center has a special designation for working with civilians so that they can keep coming back here for their follow-up care."
This program includes things like base access and includes patients from all over Texas and beyond.
Williams said the most rewarding part of her job is seeing a patient recover from their injuries.
"There's a lot that goes into their recovery," said Williams. "Large burns are very labor-intensive. When you see a patient day after day, week after week, and watch their wounds heal, especially on a large burn, there's nothing better than seeing them completely healed. At the very end, you're looking at them and it's amazing.
Williams recounted a story of watching a patient standing up during rehabilitation, after not being able to walk for nearly a year. It caught her in the moment.
"I didn't realize how emotional that would make me," said Williams.
"I think that's the best part of being a surgeon in general, really," said Williams. "Something that you've intervened on, that you've worked on has really helped someone exponentially."


title: Mr controversial package

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The De Rin family have a deep-rooted passion for fine art, with a sophisticated private collection which has been meticulously built since 1670. Raised in the presence of Venetian art and Old Masters, Jonathan’s early exposure to art was shaped his family’s Chelsea-based gallery, once by appointment to the now King Charles. Over the years, he has developed a broad appreciation for a wide-range of art—from Impressionist and Modern to Contemporary works to an emerging interest in AI and interactive art installations. He is particularly aligned with Waran’s Fine Art for its commitment to working with living artists and supporting the next generation of artistic talent.
With a background in private equity and investor relations, Marta has over a decade of experience raising capital across different sectors.Marta’s passion for contemporary art is rooted in both personal interest and academic study holding a creative art degree. Her strong connections across the finance, art, and business worlds make her uniquely positioned at the intersection of cultural and capital investment.
A Cambridge graduate Art Curator with a deep foundation in art history, Ellie brings a thoughtful and contemporary perspective to her work. Passionate about neo-pop art, she finds inspiration in its bold aesthetics and cultural commentary. As Waran’s Fine Art’s Creative Director, she thrives on collaborating directly with the artists in our roster, valuing the opportunity to explore their insights and creative visions. This connection between curation and creation fuels her approach to curation and artwork selection.
Dev Waran co-founded Waran’s Fine Art with a singular vision: to champion living artists and ensure they are recognised and rewarded during their creative journey—not just in retrospect. With a deep respect for artistic integrity and a keen understanding of the art market, Dev has created a gallery model that supports emerging talent through long-term partnerships and international exposure. His commitment to both artists and collectors redefines access to fine art, offering a more thoughtful, sustainable path to building meaningful collections.


text:
5 Pro Tips to Maximize Your Success with MyEssayWriter.ai
Welcome to MyEssayWriter.ai, your innovative partner in the journey toward academic
Imagine having a personal writing assistant who's available 24/7, equipped with the intelligence
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Explore Tips for More AI Writing Tools
Ready to level up your AI writing game even further? Check out these guides for mastering our tools that can simplify your academic and professional writing.
From essay writing to grammar refinement and readability improvement, read tips for mastering MyEssayWriter’s AI tools:
Addressing Common AI Writing Queries
What is AI writing?
AI writing involves using artificial intelligence technology, typically in the form of machine
natural language processing, to generate text that is similar to that written by a human.
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An AI writer analyzes large amounts of text data to learn language patterns, structures, and
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It usually takes 90 seconds to generate an essay, but the final time depends on the length and