title: Visitors flock to peabody

text:
As families cut back on vacations to exotic destinations, more and more New England residents are opting for local getaways, including Yale’s own Peabody Museum of Natural History.
Paid admissions to the Peabody have been up from the previous year for every month except one since the global recession began last fall, said Melanie Brigockas, the Peabody’s public relations and marketing manager. She attributed the increase in visitors to a desire to stay local, the opening of a new exhibition hall — Hall of Minerals, Earth and Space — and improved advertising.
[ydn-legacy-photo-inline id=”10404″ ]
“We have done fantastically since November,” said. “In the last 10 months we have broken numerous monthly admissions records, setting new highs in both paid and total attendance for certain months. Many people are traveling less and patronizing establishments closer to home.”
January saw the highest percentage increase in paid visitors, up 32.7 percent from last year, while February had the most paid visitors in one month, with a whopping 10,739 visitors.
March was the only month with fewer paid visitors than the previous year — unsurprising, Brigockas said, since March 2008 saw a particularly large influx of visitors.
Other natural history museums in New England said they have experienced similar increases, or at least consistent paid attendance since the recession began.
The Cape Cod Museum of Natural History had about 7,000 more visitors this summer than last summer, an increase the museum’s director attributed both to the unusually rainy weather and a desire to go local for entertainment.
“Historically we’re packed during a rainy day, but we had good beach days this summer where people still came in larger numbers,” said executive director Bob Dwyer. “It’s been a very confusing year.”
The Harvard Museum of Natural History has also done well despite the recession, recording an all-time high of more than 175,000 during the last fiscal year, according to Executive Director Elisabeth Werby.
Brigockas said the spike in visitors to the Peabody began in November with the opening of the Hall of Minerals, Earth and Space, which showcases Connecticut geology, gems and antique diamond jewelry.
Advertising, including an electronic billboard on Interstate 95 and radio promotions, has also helped raise the museum’s profile in the community.
This was nowhere more evident than at the end-of-summer bash, when more than 3,600 visitors flocked to the museum Saturday to take advantage of one of the museum’s few free admission days. Brigockas said the museum was only expecting 1,000 to 2,000 visitors.
Alexander Kline, a Peabody staff member who mans the fossil cart, said the crowd inside the Great Hall of Dinosaurs was more diverse and more interested in the fossils than he had ever seen in his year of working for the museum.
The Peabody, which charges $24 for a family of four, worked especially hard to advertise in neighborhoods whose residents could not afford the luxury of visiting a museum in the middle of the recession, Brigockas said.
Ariana Rinaldi, who brought her three children to see the exhibits, said she came after seeing the large street banner, while Cindy Milin, who was visiting from Bloomfield, Conn., with her husband, said she read about it in the Hartford Courant.
Free days and afternoons in the past have been far less successful, Brigockas said, and often ended up as glorified babysitting, with two adults supervising school groups of 50. The free Thursday afternoons became so disruptive that the museum cut them out this summer, but they plan to reinstate them this month.
Some 61,337 paying visitors have come to the Peabody since November. An additional 46,878 got in free.


tier: cub

shelf: civic-law

title: Event

text:
AECOM is actively seeking a full-time Natural Resources Biologist III for immediate employment within our Southern California Natural Resources Group. This hybrid position is primarily office-based, though some field work may be required and can be based in any of our Southern California offices including San Diego, Los Angeles, Orange, Long Beach or San Luis Obispo.
This position would support numerous natural resource projects in the southern and central California region with a focus on leading preparation of Biological Assessments, Habitat Conservation Plans, technical reports, and other regulatory compliance and permitting efforts including CEQA/NEPA, 404/401, CESA, and ESA resource agency consultation.
Primary duties include authoring on complex technical documents for large-scale projects, developing permitting strategies for clients, synthesizing compiled datasets, collaborating with a large team of technical experts, and task management. The ideal candidate has a strong technical background and advanced writing skills and is interested in moving towards a Project Management trajectory. Familiarity with Sections 7 and 10 of the federal Endangered Species Act, 2081 permitting under the California Endangered Species Act, NEPA, CEQA, and the Clean Water Act are required. A 10(A)(1)(a) permit for listed species local to southern California is preferred (but not required), including species such as coastal California gnatcatcher, desert tortoise, and/or southwestern willow flycatcher amongst others. Additional duties may include financial management tasks and team coordination/leadership. Position will support multiple project managers on a variety of types of projects including utility, military, transportation, and renewable energy sectors.
For more information, and to apply: https://aecom.jobs/san-diego-ca/biologist-iii/8AE7B66F330746B8A968CAD2B06CBCED/job/
Starts: October 23, 2024 16:00pm
Ends: November 29, 2024 15:41pm


shelf: science-engineering

title: Revolution in sustainable fish dining

text:
Hamburg-based food tech startup, Bluu Seafood, is set to launch its lab-grown vegan fishballs in Germany. As the first company in Europe to offer cell-based fish meat, Bluu Seafood aims to meet the growing demand for fish products while addressing the issue of overfishing. Founder Sebastian Rakers believes that cell-based fish has the potential to feed a large portion of the population without harming the environment or the animals themselves.
Bluu Seafood's cell-based fish is grown in a lab, which means that no fish are killed in the process. This sustainable method of food production not only protects marine ecosystems from overfishing but also contributes to the United Nations Sustainable Development Goals (SDGs). The SDGs aim to end poverty, protect the planet, and ensure that all people enjoy peace and prosperity. One of the SDGs, in particular, is SDG 14, which focuses on conserving and sustainably using the oceans, seas, and marine resources. Bluu Seafood's vegan fishballs align with this goal by providing a sustainable alternative to traditional fish products.
Founder Sebastian Rakers has been working on isolating fish cells since 2008 and is thrilled with the rapid progress his company has made. Aside from being a more ethical option, cell-based fish is also free from harmful pollutants and minimizes the use of resources, making it an attractive option for those who prioritize sustainability.
In light of the increasing demand for protein and the challenges posed by climate change, there is a need for a global conversation about sustainable food production. Bluu Seafood's vegan fishballs are an innovative solution that could contribute to the achievement of a sustainable food system.
Bluu Seafood's cell-based vegan fishballs are not just a culinary innovation but a step towards a more sustainable future for the planet and its inhabitants. By aligning with the Sustainable Development Goals, Bluu Seafood is contributing to the vision of a global society that prioritizes environmental and social well-being.


tier: polar

shelf: software-docs

text:
On Thu, Oct 27, 2011 at 10:36 AM, Mick wrote:
... made the change but it didn't work, if I can't find what they butchered this time before the night freight train to Cairns grinds past in half an hour I'll give up and re-install tomorrow.
If you can't fix it in the current install, how is a re-install going to just "magically" fix things? Did you check .pacnew files? Have you messed up files that are changing the behavior of your system? You likely did not. The default behavior of stuff does often change. This is often due to upstream changes of packages. Many other distros try hard to shield you from those changes by over tweaking the defaults and always finding alternatives to upstream changes. They can become distanced with where the upstream really is. Arch is a lot more transparent in that regard, the end user is less shielded by the continual change within the free software community that provides the upstream for GNU/Linux and BSD systems. If you can't deal with being so exposed to upstream changes and are willing to adapt (like by learning udev rules to automatically let you use common usb media as a regular use) then Arch is likely not for you. If a re-install to fix your system you are doing it wrong. Fix the problems in your existing install or they will just come right back. Ok, if you have tweaked all your settings to no avail and have broken the system yourself, then yes, a re-install would give you a clean slate. Arch is not like windows was 10 years ago where you had to reinstall every 6 months just to get a stable system again. There is no "registry" in arch that one has to continually clean. With Arch you research problems and get to the bottom of what is causing it, and fix it, and learn a lot in the process. In the past year I can only think of only two updated packages that made me have to intervene BEFORE things broke: 1) changes in network configuration 2) changes in kernel naming There were other changes, but they were easy enough to just deal with as they happened. USB stuff did change, but since I'd already been writing udev rules for other stuff, it did not really affect me. Arch Linux should not be promoted as a system that will just work for you if you are not willing to get your hands dirty and research things to fix them. In my opinion Arch Linux is really for those who really would be better off running Linux From Scratch http://www.linuxfromscratch.org/ if they had the time and energy to do so, but want to use a distribution that takes care of all the laborious stuff so they can other stuff with their system(s). Arch is for experienced Linux users alreeady proficient at a nitty gritty configuration level, or those who want to become that type of user, and Arch goes out of it way to cater towards that type of user, and help you become that type of user.


shelf: health

title: Pharmacies integral to preventing ill health if pms plans are to succeed

text:
Community pharmacies are integral to the Prime Minister’s ‘Reforming Elective Care for Patients’ plan, the Company Chemists’ Association says.
The plan, which was published Monday (6th January), talks about making more appointments available in the community instead of hospitals and greater patient choice and convenience, amongst other things.
Malcolm Harrison, Chief Executive of the Company Chemists’ Association said: “Solving the NHS’ strains will only be possible if people can access the right care, in the best place, as soon as possible.
A greater proportion of funding must go into primary care if patients are to access the care, they need from the NHS.
Pharmacies are well placed to diagnose and prevent ill health, with most people in England living within a 20-minute walk of their local pharmacy.
However, having experienced a 40% real-terms cut in funding since 2015, and 1,200+ closures since 2017, pharmacies urgently need an uplift in funding so they can continue to provide the ‘walk-in’, extended hours, access that people need and expect.”
Another part of the ‘Reforming Elective Care for Patients’ plan focuses on maximising ‘pharmacy first approaches’ to ear, nose and throat (ENT) services and “developing one-stop clinical models to support patients needing ear care and patients with rhinitis”.
Harrison said: “We absolutely support a Pharmacy-First style approach to ear, nose and throat services. Pharmacy First has proven to be a success in a short space of time, and expansion into new conditions will ensure even more patients benefit.
If the Government and NHS England are serious about shifting care into the community, as well as freeing up GP capacity, they should consider how they can help turbocharge Pharmacy First”.
Community pharmacies must play a significant role in elective patient healthcare for the Prime Minister’s new plan to succeed at reducing appointment backlogs and wait times.


shelf: finance

title: Magento mobile app builder

text:
Optimizing operations and providing exceptional customer experience is the way to stay in the heart of your customers, or they might not think twice before switching.
With the increasing influence of mobile devices, having a mobile app has become essential for businesses to stay competitive in the market.
Magento, a leading e-commerce platform, is used by many businesses. Mobile app builders like MageMob are the best solution for businesses to streamline their operations and provide a seamless shopping experience to their customers.
MageMob is affordable and the fastest way to build a fully functional, feature-rich mobile application.
Let’s discuss the features and benefits of Magento 2 Mobile App Builder and explore how it can revolutionize your business.
Understanding the Importance of Mobile Apps in E-commerce
- In recent years, there has been a significant surge in mobile commerce, with more and more consumers preferring to shop through their smartphones and tablets. This trend highlights the importance of having a mobile app to tap into the growing mobile market.
- Customers expect convenience and instant access to products and services. Mobile apps provide a user-friendly interface that allows customers to browse, shop, and make purchases easily.
- If businesses fail to adapt to this shift in consumer behavior, there is a high risk that you will lose your customer to the competitor.
Benefits of Having a Mobile App
- Mobile apps offer a more personalized experience compared to mobile websites, allowing businesses to engage with customers more effectively.
- By offering exclusive discounts, personalized recommendations, and rewards through mobile apps, businesses can build stronger and loyal relationships with customers.
- Mobile apps boost conversion rates as it is easy, fast, and convenient to use an app while purchasing a product.
What is MageMob?
MageMob is a Magento Mobile App Builder, a feature-rich extension that allows businesses to create fully customized mobile apps for their Magento-based e-commerce stores.
It provides seamless integration between the app and the Magento store, enabling businesses to manage both platforms effortlessly.
Using MageMob, it is possible to develop an Android and iOS app within two days, the fastest and the most affordable way to develop mobile apps.
Key Features of MageMob
Customizable App Design
Magento Mobile App Builder offers a range of design templates and customization options, allowing businesses to create visually appealing apps that align with their brand identity.
Seamless Integration with Magento Store
The App Builder ensures real-time synchronization between the mobile app and the Magento store, enabling businesses to manage inventory, product catalogs, and customer data efficiently.
Businesses can send push notifications to app users, notifying them about new products, promotions, and order updates. Real-time updates ensure customers stay informed and think of your app when they need something.
Personalized User Experience
The app builder incorporates advanced personalization features, such as personalized recommendations, that enhance customers’ overall shopping experience.
Secure Payment Gateways
Magento Mobile App Builder supports secure and convenient payment options, allowing customers to make transactions confidently. Businesses can integrate the payment gateways that they use.
Social Media Integration
Integrating popular social media platforms enables businesses to expand their reach and attract new customers. It is a must-have feature to look for in a mobile app builder.
Streamline Operations with MageMob
Inventory Management and Order Processing
MageMob streamlines inventory management by providing real-time synchronization with the Magento store. This means the stock levels are accurately reflected in the app to prevent overselling. Businesses can efficiently process orders directly from the app, improving operational efficiency.
Simplified Catalog Management
With the App Builder, businesses can easily update and manage their product catalogs, like adding new products, modifying prices, updating product descriptions, etc. These changes are instantly reflected in the mobile app, ensuring customers always have access to the latest offerings.
Efficient Customer Support and Communication
MageMob offers built-in customer support features, such as live chat and support tickets, to provide prompt customer assistance. It helps the support team address customer queries, resolve issues, and enhance customer satisfaction.
Enhancing Customer Experience with MageMob
Mobile-Friendly Interface and Navigation
The App Builder ensures a mobile-friendly interface with intuitive navigation, making it easy for customers to browse products, access categories, and search for specific items. MageMob’s well-designed and responsive interface enhances the overall user experience.
Easy Checkout Process
The App Builder simplifies the checkout process, allowing customers to complete their purchases quickly and effortlessly. Integration with secure payment gateways ensures a smooth and secure transaction experience. One-page checkout helps minimize cart abandonment rates.
Loyalty Programs and Rewards
By integrating loyalty programs and rewards into the mobile app, businesses can make repeat purchases. Moreover, exclusive discounts, referral programs, and points-based rewards encourage customer loyalty, driving long-term growth for businesses.
Mobile apps have become crucial for businesses to thrive in the competitive e-commerce market. MageMob offers a comprehensive solution that streamlines operations and enhances customer experience. By leveraging the key features and functionalities of Magento 2 Mobile App Builder, businesses can create customized mobile apps, streamline inventory and order management, provide personalized user experiences, and increase customer loyalty and sales. For more information, connect with our team for more information.
All product and company names are trademarks™, registered® or copyright© trademarks of their respective holders. Use of them does not imply any affiliation with or endorsement by them.


shelf: education

title: Facilitating Group Learning

text:
Facilitating Group Learning
by George Lakey
reviewed by Jonathan Betz-Zall
Adults learn best through well-managed conflict, especially in multicultural groups, says George Lakey, one of the most prominent practitioners of satyagraha – the force of truth as the universe arcs toward justice. Originally published in 2010, this second edition of Lakey’s pathbreaking book appears to be aimed at college and university instructors, but it brims with insights for educators of adults in many other settings: training for social justice and social service work, professional and technical training, and even religious education that values experience as well as book learning. Our best efforts as Friends take the form of leading each other toward truthful insights through respectful, cooperative arguments over ideas. George Lakey shows us how to follow this leading.
Through many years of training practitioners of nonviolent direct action, Lakey developed a practice he calls “Direct Education,” which “supports the emergence of conflict, then assists the group to expand to a new level of performance and eagerness to learn.”
“In Direct Education, teachers are proactive” – they carefully set-up learning exercises and organize small support groups. They reinforce positive behaviors and generally work to create a pro-learning social order, or “container”. The teacher coaches learners to leave their comfort zones behind and to courageously enter the “learning zone.” A strong container allows teachers to manage positive relationships between “mainstream” and “margin” subgroups within the class. For example, “This generalization may fit many of you, but I imagine some of you have a different experience.” Developing and maintaining this container from the very beginning is key to influencing and benefitting from the “secret life” of the group, which can harmonize a multiplicity of individual learning goals.
Once a strong container is built, teachers can go on to effectively address differences by acknowledging, supporting, and confronting them. Lakey advises a process here of “showing rather than telling.” “Confronting [oppressive attitudes in] participants from the place of facilitator or teacher takes unfair advantage; it loads the dice because of people’s learned attitudes toward authority. Participants who habitually deferred to authority would simply defer to me, no matter what actually moved within them. Who can call that a learning process?” Lakey offers several participatory learning activities that “show rather than tell,” including speak-outs and fishbowls.
Following his own advice, Lakey tells story after story in this book – about how he had to change his own mind in response to class situations and how the principles of Direct Education were formed and successfully applied. Even experienced teachers who have already tried some of these methods will learn from his examples and see the principles in action in unexpected places, like Friends meetings.
While he occasionally acknowledged Quaker support of his work, Lakey leaves it to Quaker readers to envision how his principles could work for us. Friends who worry about lack of ethnic diversity in our meetings could benefit from the chapter on “Authenticity, Emotion and Expression.” We could consider how to strengthen the container and the mini-containers in our groups, support projection of feelings onto objects, give permission to nonverbal expression [e.g. to yawn], draw a cognitive map to reassure those who need some theory, and watch and encourage the margins in the group. The increased level of authenticity would very likely draw people who would increase our meeting’s diversity – if we are willing to allow ourselves and our meetings to be transformed. Are we ready to enter a learning zone? ~~~
Jonathan Betz-Zall is a member of University Friends Meeting in Seattle, WA (NPYM).


shelf: home-craft

title: Erlewine shopstand

text:
Dan Erlewine shows how his ShopStand replaces a workbench for guitar repair, buffing, and all instrument work.
Dan Erlewine: I'm Dan Erlewine and this is the ShopStand. It's a solid column mounted to the floor. It's height adjustable and it rotates, supported by this roller bearing. I used to have my workbench mounted right here, and I replaced it with the ShopStand because it takes up so much less space, it's less wobbly, and it does a lot more.
Right now I have my Neck Jig clamped into an Angle Vice that I bolted to the ShopStand. With this, I can tip a guitar into the playing position and lock it there while I do fret work or setup work. With a repair vice and a scrap of carpet, this has become my main workstation.
Uses for the ShopStand
There's a lot of uses for a solid stand like this, especially if you have the angle vice, because any tool that has a wooden base can be clamped in and out of it, in seconds. Like right now, I have my belt sander in it, and it's the perfect height for making nuts and saddles. Without having to cut down on my knees, I bring the work to me.
The ShopStand is drilled to accept the Guitar Repair Vice. It's also drilled and tapped to accept an angle vice, which holds anything. This buffer hangs on my wall when I'm not using it, and the ShopStand is the perfect buffering stand. It's so solid and rigid.
Here's a buffing tip. Keep the piece moving and move in circular motions, sort of like that, like steering a car. That's the way they do it at Gibson, and you won't get streaks in one direction that way.


shelf: history-culture

title: Karen bass black mayor responds trump deploys national guard los angeles first time since rodney king riots

text:
Nationwide — For the first time since the 1992 Rodney King uprising, a sitting U.S. President has deployed the National Guard to Los Angeles without a formal request from the city or state. President Donald Trump authorized the deployment of 2,000 National Guard troops to respond to escalating immigration protests, sparking immediate backlash from California leaders—especially from L.A.’s Black mayor, Karen Bass, who condemned the move as “dangerous and unnecessary.” The protests erupted after a new wave of ICE raids swept through immigrant communities across L.A. County, triggering fear, outrage, and violent clashes with federal agents.
Time reports that Mayor Bass, a veteran community organizer and former Congressional Black Caucus chair, urged calm while slamming the federal response. “We will not allow this city to be turned into a war zone,” she said in a televised address. “Every Angeleno has the right to protest—but military force against civilians is not the answer.” Bass said city officials had not requested federal troops and accused the Trump administration of seeking to “provoke violence for political theater.” Her statement came just hours after National Guard troops arrived at several federal properties across the region.
Trump, however, doubled down. On Truth Social, he accused protesters of being “radical left agitators” and called for a ban on masks at protests. “What are they hiding?” he wrote. Defense Secretary Pete Hegseth confirmed that active-duty Marines stationed at Camp Pendleton were also on standby. California Gov. Gavin Newsom, who called the deployment “purposefully inflammatory,” warned that Trump was “manufacturing a crisis to justify more authoritarian control.”
This deployment marks only the third time in modern history that the National Guard has been sent into L.A. in response to civil unrest—following the 1965 Watts rebellion and the 1992 Rodney King riots. But unlike past events, this latest action bypasses state leadership altogether. “No governor or mayor asked for this,” said Sen. Bernie Sanders, calling Trump’s move “a clear step toward authoritarianism.” Civil liberties groups including the ACLU have threatened legal action, calling the deployment “a declaration of war on Californians.”
The protests were sparked by aggressive ICE raids, which have reportedly resulted in more than 2,000 arrests nationwide this week, with 118 in L.A. alone. Activists and immigrant rights organizations say federal agents used excessive force and failed to show warrants. In downtown L.A. and Paramount, demonstrators lit fires, clashed with officers, and blocked intersections. Over 120 people have been arrested, according to federal authorities. “We belong here,” said one organizer from the Coalition for Humane Immigrant Rights. “And we will not be silenced.”
As tension builds, Mayor Bass continues to urge nonviolence while rejecting the federal militarization of the city. “Let history remember,” she said, “who stood for unity—and who brought soldiers into our neighborhoods to silence dissent.”


text:
Canada- $20 million clergy sex settlement
For immediate release: Tuesday, Aug. 12, 2014
Statement by David Clohessy of St. Louis, Director of SNAP, the Survivors Network of those Abused by Priests (314 566 9790, [email protected])
A $20 million clergy sex abuse settlement means one thing: Catholic officials were incredibly scared of the evidence about complicity that would have emerged in court.
That's almost always the motive when the church hierarchy pays this much money to abuse victims.
We applaud these brave men and women for having the strength to report these crimes, the wisdom to seek justice in court and the tenacity to endure needless legal delays by Redemptorist officials. Kids are safer today because of the courage of these victims. We hope their action will prevent future abuse and cover ups. And we are confident that their healing will be helped by this resolution.
No amount of money can restore the stolen childhoods and shattered trust of these once-innocent and trusting children. Those who committed or concealed these heinous crimes should be in jail. But the civil justice system can help validate those who have been severely and needlessly harmed, and that's what we believe happened here.
We hope the bravery of these victims will inspire others who saw, suspected or suffered clergy sex crimes and cover ups in Canada to speak up, get help, expose wrongdoers, protect kids and start healing.
(SNAP, the Survivors Network of those Abused by Priests, is the world’s oldest and largest support group for clergy abuse victims. We’ve been around for 25 years and have more than 18,000 members. Despite the word “priest” in our title, we have members who were molested by religious figures of all denominations, including nuns, rabbis, bishops, and Protestant ministers. Our website is SNAPnetwork.org)


title: Frequently Asked Questions

text:
Frequently Asked Questions
If you haven’t found the answer you need,
email us at email@example.com!
What is Smarter Snacks?
Treat yourself to healthier choices!
Introducing Smarter Snacks, where delicious meets nutritious. Whether you're on the go or simply craving a smarter option, our carefully curated selection ensures you never compromise on taste or quality.
Explore our range of guilt-free snacks that satisfy every craving without the regret. From wholesome granola bars to refreshing fruit blends, each bite is packed with goodness to fuel your day.
Make the smarter choice today with Smarter Snacks. Because every bite should be a step towards a healthier you.
What are the benefits of High Protein snacks?
High protein snacks provide numerous benefits that can support overall health and wellness. Firstly, protein enhances satiety, helping to curb hunger and reduce overeating tendencies. It also plays a crucial role in muscle maintenance and repair, making it beneficial for those involved in physical activity or looking to build lean muscle mass. Additionally, protein-rich snacks can contribute to better metabolic function, as protein requires more energy to digest compared to carbohydrates or fats, potentially aiding in weight management efforts. Moreover, consuming protein helps regulate blood sugar levels, minimizing spikes and crashes that can lead to cravings and energy slumps throughout the day. Incorporating high protein snacks into your diet can therefore promote feelings of fullness, support muscle health, regulate metabolism, and maintain steady energy levels.
What Type of Sweeteners does Smarter Snack Use?
Our products at Smarter Snacks use honey as the sweetener. Honey is chosen for its natural sweetness and distinct flavor, offering a healthier alternative to refined sugars. It also aligns with our commitment to using natural ingredients.
Do protein snacks help with weight management?
Yes, incorporating protein snacks into your diet can support weight management goals by promoting satiety and reducing cravings for unhealthy snacks. Protein also requires more energy to digest, which can slightly increase calorie burning.
Are protein snacks suitable for children?
Protein snacks can be a nutritious option for children, especially those involved in sports or physically active. It's important to choose snacks that are appropriate for their age and dietary needs, ensuring they get balanced nutrition without excess sugar or additives.
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title: 24 hours to improving chuljangmasaji

text:
An evening out While using the boys till the wee hrs from the morning, a party with good friends, a nice romp during the hay with a woman. The standard companions to those well-known pastimes are alcohol and tobacco. In truth, the extremely idea of party or night out is inextricably connected with Alcoholic beverages intake, even if using tobacco is just not that well-known anymore.
Nevertheless, although drinks and smokes make the get together infinitely superior, ending the bash in the bed with another person could become a little a dilemma. It is just a very well-recognized fact that Liquor and intercourse don’t blend nicely. Genuine, a glass or two is often calming and even arousing, but an entire bottle of hard liquor could be the swiftest method to a limp noodle. Some youngsters https://www.msg114.com/ can in fact pour many Alcoholic beverages down their throats without lacking out on Bed room efficiency, but weighty consuming suggests impotence faster or afterwards.
Smoking is just as poor for the intercourse daily life as Alcoholic beverages. Despite the fact that you will nonetheless have the capacity to perform in bed, your lungs and heart will not be capable of sustain Along with the increased exertion. Pretty soon you’ll find yourself wheezing and compelled to assume a more passive function in an effort to help save your toughness. And this even before thinking about the destructive http://www.thefreedictionary.com/출장마사지 result using tobacco has on fertility in both equally Males and girls.
Following sex, cigarettes are a pleasant touch towards the afterglow of a shared orgasm, but a variety of scientific tests show that forty% of smokers are impotent. Smoking cigarettes improves the chance of impotence by some 50% for guys of their 30’s and 40’s. This means that lots of Males who would otherwise be perfectly wholesome, at the moment are impotent just because they favored to smoke. It looks like a bitter tradeoff


title: Safety and efficacy of a hydrogel inlay with laser in situ keratomileusis to improve vision in myopic presbyopic patients one year results

text:
To study the safety and efficacy of implanting a hydrogel corneal inlay (Raindrop Near Vision Inlay) concurrently with performing laser in situ keratomileusis (LASIK) to treat myopic presbyopia and to compare the results with results of the same treatment in emmetropic and hyperopic patients.
Two private clinics, Tijuana and Monterrey, Mexico.
Prospective nonrandomized clinical trial.
Bilateral myopic LASIK was performed and a corneal inlay was concurrently implanted in the nondominant eye under a flap created using a femtosecond laser. Primary safety outcomes were the retention of corrected distance (CDVA) and near (CNVA) visual acuities. Efficacy was evaluated on the basis of uncorrected near (UNVA), intermediate (UIVA), and distance (UDVA) visual acuities. A patient questionnaire was used to assess the preoperative and postoperative incidence of visual symptoms, the ability to perform common tasks with no correction, and patient satisfaction with vision.
Thirty eyes were enrolled. At each postoperative visit, the mean CDVA and CNVA were within one half line of preoperative measurements and no eye lost 2 or more lines of CDVA. The mean binocular UDVA, UIVA, and UNVA were better than 20/25 Snellen at all postoperative visits. By 6 months, 93% of patients had a binocular Snellen acuity of 20/25 or better across all visual ranges. According to patient questionnaires, 1 year after surgery, visual symptoms were at preoperative levels, 98% of all visual tasks could be easily performed without correction, and 90% of patients were satisfied or very satisfied with their overall vision.
A hydrogel corneal inlay with concurrent LASIK was safe and effective for treating myopic presbyopia.
Drs. Garza and Chayet are consultants to and investigators for Revision Optics, Inc.


title: Welcome to the MAYURAA GROUP

text:
Welcome to the MAYURAA GROUP
MAYURAA GROUP has earned the reputation of being one of Chennai’s most trusted realty companies
MAYURA GARDENINGS is a distinguished firm specializing in landscape design and execution, with a legacy dating back to its establishment in 1986. With 38 years of profound experience and a formidable reputation in the industry, we have had the privilege of orchestrating numerous prestigious turnkey projects. Our portfolio showcases a collection of remarkable endeavors. We have expanded our scope to include construction services. As builders and contractors under the name of “MAYURAA BUILDERS AND PROMOTERS”, we are dedicated to catering to the diverse needs of homebuyers, ensuring their utmost satisfaction. Our offerings encompass a range of construction options, from affordable housing to premium quality residences, all meticulously crafted to meet the highest standards of excellence. Today, we are pleased to announce the consolidation of all our endeavours under a unified entity known as “MAYURAA GROUP”.
Looking for Exceptional Home Builders in Chennai ?
Are you searching for top home builders in Chennai who offer premium service at a budget-friendly price? You’ve come to the right place to turn your dream plans into reality. We excel in crafting stunning designs and customizing elements based on digital models for both residential and commercial spaces. From 2, 3, and 4 BHK villas to turnkey solutions and civil projects, we provide exceptional quality while ensuring affordability.
Quality is our main motto. Quality construction starts with our customers by consulting with you.
We consult with our group of experts and we design as per the structural design that builds to last over 60 years.
Time is everything in this field we scheduled every work of your project before we start and you start count on us.
MADE WITH LOVE
We love our work. We are not building we are crafting your dreams.
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title: News

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April 8th was the start of something spectacular! Four groups participated in the student vs. teacher basketball game: freshman (black jerseys), juniors and sophomores (white jerseys), seniors (purple jerseys), and teachers. There were three games total, each consisting of two, give minute matches. The first two games acted as elimination games to see what what grade level would play against the teachers.
The first game was the freshman vs. the juniors and sophomores. The juniors/sophomores started the game with two lightening fast scores. Freshman were able ot grab hold of the ball, but it was snatched back by the juniors/sophomores and they scored once again. Each team performed some nice spins while chasing after the ball, but the juniors/sophomores obliterated the freshman with a final score of 21 to 6. The second game was between the juniors/sophomores and seniors. Right off the bat, one can see that was going to be a close match; the juniors/sophomores and seniors went back and forth until the juniors/sophomores got the first point. At one point during the game, the juniors/sophomores performed an outstanding dunk; however, they do not get the point. The game ended with the senior’s victory of a final score 14 to 9.
After an amazing half time performance by the cheerleaders, the final game arrived: seniors vs. teachers. This had to eb the best game out of them all. The seniors did a good job blocking the teachers, but the teachers found a hole and made the first score of the game. This was a close game, much like the last one. One person who stood out in particular was Coach Lewis. He was, by far, the best blocker and proved to be a huge handicap to the seniors by scoring five times. The final score was 12 to 9, with the teachers being victorious.


title: How to grow bay

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Used for its striking appearance and its strong flavours, bay is one of the oldest plants in cultivation.
It’s a staple in any herb garden is used fresh or dried in soups and stews. Because bay is a tree that’s easy to shape and can grow as high as 8m, it’s a topiary favourite too. For flavouring, bay leaves can be harvested at any time of the year.
Bay is a relatively straightforward plant to care for too. It can be planted in the ground and does equally well in a pot. Read on for more on how to grow bay.
Bay is commonly found in garden centres and can be planted throughout the early spring and summer months, typically from March to June. Young bay plants can be planted as soon as any frosts have passed.
If you’re planting your bay in the ground, dig in some compost and if you are planting your bay in a pot, a soil-based compost also works. In both cases you might want to add some grit for drainage. Your bay needs regular water but won’t thrive if its roots become waterlogged, so ensure adequate drainage for the roots. Young plants should be sheltered from full sun and wind if possible as these are more delicate.
Water the plants well and often for the first few weeks while the plant settles.
Bay grows slowly but will eventually grow into an 8m high tree if not clipped for shape and size. But most bay is trained to grow for topiary purposes, commonly trimmed into shapes such as balls or cones. In this way growing bay is an easy way to add a formal touch to a garden, or you’ll often find a couple of potted bay trees standing either side of a porch.
Except in drier climes, any bay that’s in the ground should get enough water from rainfall. Don’t allow your bay to dry out but any excess should be allowed to drain away as a bay doesn’t like its roots waterlogged. Add a little plant food every month. If your bay is in a pot, then you will need to repot it at least every three years. Once bay has established it can handle full sun.
But if you’re concerned about how to grow bay during the winter the following should help. Frost and freezing conditions can severely damage bay. Move your plants inside if you can, or use the shelter of a porch. If temperatures drop below -5° the roots can become susceptible. If you can’t move the tree, consider wrapping it in a fleece or bubble wrap.
In the summer you can prune, in the spring cut back to rejuvenate the plant.
Plants do get problems and part of understanding how to grow bay is dealing with them when they arise. For the most part growing bay is fairly trouble free. Frost damaged leaves, those that are black or brown, can be picked off or trimmed in the spring. Yellow leaves can be a sign of waterlogged roots or not enough nutrients.
If you discover discoloured and curled up leaves or those that are sticky bay leaf suckers could be the problem. Sap-feeding bay leaf suckers are winged insects that attack young bay foliage, but can be dealt with by removing the offending leaves. Bigger outbreaks might require pruning. Vine weevils or scale insects can cause similar symptoms.
Fresh bay leaves are used in cooking can be harvested throughout the year, picked as required. If you want dried bay leaves, dry out individual leaves or entire sprigs in a warm place, then store in an airtight container up a to a year.
How to grow bay is part of the VegTrug Grower’s Guide.


title: Disneys award winning mary poppins musical is heading to australia in 2023

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The world's favourite nanny is flying into Melbourne next year.
Winds in the east, mist coming in, like somethin’ is brewin’ and ’bout to begin … an Australian production of a timeless classic is heading to Melbourne next year. With leading lady Marina Prior, who originated the role of Mrs Banks in the original Australian 2010 production, returning to Cherry Tree Lane to star in the dual roles of Bird Woman and Miss Andrew. Mary Poppins will be playing at Her Majesty’s Theatre for a season that commences on January 29, 2023.
The key takeaways
- Mary Poppins the musical is coming to Melbourne, Sydney and Brisbane
- Musical theatre icon Marina Prior joins the cast, returning to the musical after having played Mrs Banks in the show’s 2010 run
- It all goes down in 2023, for a season in Melbourne from January 29 until April 2
Stay up to date with what’s happening within the region’s theatre and art scene here.
The original stage production of Mary Poppins had already charmed the world prior to the Australian premiere season, having won Olivier, Tony, and Evening Standard awards for the West End and Broadway productions. Opening in 2010, Melbourne audiences wholeheartedly embraced Mary’s magic, as Mary Poppins shattered Australian box office records before going on to win a record-breaking eight Helpmann Awards.
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Now, a new generation of Australians have joined the tens of millions of people worldwide to experience Mary’s magic, with the new production that opened in Sydney in May 2022. Adapted from the original stories by Australian author PL Travers and the beloved 1964 Disney film, the story of the world’s favourite Nanny is brought to life on stage by dazzling choreography, incredible effects, and unforgettable songs.
“I am thrilled that my latest Poppins has been embraced with even greater joy than the original with a phenomenal cast in an even more spectacular production that celebrates the joy and elation of live theatre, in a way that very few other shows can,” says Cameron Mackintosh, the theatrical producer of Mary Poppins.
“I’m looking forward to Melbourne audiences stepping in time to the theatre early next year, where they are guaranteed a show that is ‘Practically Perfect in every way’!”
Tickets are on sale from Monday September 19. Grab your tickets before they fly away by heading here.


title: Oregon judge orders release of loran beck after illegal prison sentence extension

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For nearly a year, Loran Beck was convinced he didn’t belong in an Oregon prison—even though the governor had sent him there. On Sept. 19, a Multnomah County judge agreed. After hearing Beck’s case, Judge Michael Greenlick ordered his immediate release, stating that Beck had already served eight months longer than legally required.
Beck, 46, is part of a growing group of inmates who have successfully challenged Gov. Tina Kotek in court and secured their freedom. Four people have won cases arguing that Kotek illegally extended their sentences by revoking their commuted sentences. Another case is pending.
This trend raises concerns among advocates for the incarcerated. They worry about how many others might be in prison under similar circumstances. During the pandemic, former Gov. Kate Brown commuted the sentences of over 1,000 prisoners. However, since taking office in 2023, Kotek has revoked at least 122 of these commutations, sending people back to prison. In cases like Beck’s, courts have ruled these actions unconstitutional.
Beck’s attorney, Malori Maloney of the Oregon Justice Resource Center, criticized the governor’s handling of these cases, saying, The governor should have corrected her error as soon as it became clear that their imprisonment was unlawful.
The governor’s office has remained largely silent on the matter. Spokesperson Roxy Mayer provided only a brief statement, noting that each case is reviewed individually and that the governor respects the court’s decision.
Beck’s legal troubles began in 2019 when he was convicted of felony aggravated theft and sentenced to 36 months in prison, followed by 24 months of supervision. In 2021, Brown commuted the final 11 months of his sentence, converting it to supervision. Beck was scheduled to complete his sentence in early 2024.
However, in June 2023, Beck was charged with assault. Although he was allowed to remain free while the case progressed, Kotek revoked his commutation, sending him back to prison in November 2023—just two months before his supervision period was set to end. Despite pleading to a minor assault charge, which required just 17 days in jail, Beck remained in prison for months.
Beck’s confusion and frustration grew as he tried to understand why he had been sent back to prison. He asked numerous officials for answers but was met with vague responses. In July, the Oregon Justice Resource Center took on his case, filing a petition that eventually led to his release.
Upon hearing the court’s ruling, Beck was overwhelmed with emotion. It moderately restored my faith in the justice system, he said. He was met with applause from his fellow inmates as he packed his belongings and left the prison within hours.
Though Beck is grateful for his release, adjusting to life outside has been challenging. He lost valuable tools while in prison, his motorcycle was stolen, and he’s now working part-time, unsure of what the future holds. He’s also considering leaving Oregon, feeling uneasy about his safety in a state where his freedom was taken so abruptly.
I just don’t feel safe here anymore, he said, contemplating a move far from the state he once called home.


title: Illuminate your underwater journey with the aplos ap01 dive light

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The APLOS AP01 Dive Light is a compact yet powerful companion for divers, offering exceptional brightness and reliability for underwater exploration. With a maximum output of 1050 lumens and a color temperature of 5000K - 5700K, this mini dive flashlight delivers a cold white light beam that assists in observing targets up to 170 meters (558 feet) away.
Equipped with three lighting modes, the AP01 allows for easy adjustment of brightness levels with a button switch located behind the light's head. Whether you require maximum brightness, low illumination, or SOS signaling, this diving light provides the versatility to meet your specific requirements.
The AP01 Dive Light boasts a long battery life, thanks to the included 3000mAh rechargeable battery. With a continuous runtime of up to 1.5 hours at the high mode, you can enjoy extended underwater adventures without worrying about running out of power. The added convenience of a USB charger allows you to easily recharge the battery using a computer, power bank, or wall charger. The battery indicator design provides a clear indication of the battery power level, ensuring you stay informed during your dives.
Built to withstand the demands of underwater environments, the AP01 features a rugged construction. Made from AL-6061-T6 aircraft-grade aluminum, it offers excellent durability and resistance to abrasion and seawater corrosion. With its IPX8 waterproof rating and three extra O-rings for added sealing, this professional diving flashlight can be safely submerged up to 100 meters (328 feet), making it suitable for various diving and snorkeling activities.
The AP01 Dive Light is designed for easy one-handed operation, with a convenient bottom switch for quick and effortless on/off functionality. Its compact size and portable design make it an ideal choice for scuba diving, fishing, salvage operations, underwater photography, as well as camping and hiking adventures.
In summary, the APLOS AP01 Dive Light combines superb brightness, versatile lighting modes, long battery life, and durable construction, making it a reliable companion for underwater exploration. Illuminate your path and discover the wonders of the underwater world with the AP01 Dive Light by your side.


title: Connect%20data%20connector

text:
Thanks to our Data Connector, Mobility Work provides you with a set of database tables containing your network's maintenance data.
This data can be consulted via a Business Intelligence interface or - quite simply - with Microsoft Excel ( ODBC connection).
Aggregating and analyzing this data provides crucial information on equipment performance, maintenance trends and opportunities for improvement.
By combining this data with other relevant sources (MES, for example), it is possible to obtain a comprehensive overview that can be used to optimize maintenance programs and ensure ongoing equipment availability.
Our solution therefore offers added value to maintenance managers, enabling them to effectively manage and make optimum use of plant maintenance data.
Our OBDC connector is agnostic: you can connect it to different Business Intelligence systems, even Excel.
Connexion Power B.I.
- Connecting to PowerBI is very simple. You just need to fill in the following fields:
- Database type: MySQL database
- Server host: domain name provided by Mobility Work
- Database name: provided by Mobility Work
- Username: provided by Mobility Work
- User password: provided by Mobility Work
Since August 22, 2022, we've been experiencing a problem with connectors 8.0.17 and newer. If you're having trouble, try downloading an older version here (worked fine with 8.0.16)
Libre Office Connexion
Create a new database connection
- File > New > Database
- Choose to connect to an existing database
- Choose the "MySQL/MariaDB" type
3 steps are required to connect Mobility Work data to Excel
- Add the MariaDB driver (the "technology" used by the Mobility Work database) to Windows.
- Connect our database to your Windows (add a data source in Windows)
- Connect your Excel to this data source.
Add the MariaDB connector to your Windows
Download the connector : Download
Once downloaded: install the connector
Add Mobility Work database as data source
In your control panel, enter the term "ODBC" in the search bar
Check that the connector is correctly installed
In the "User data source" tab, you can add the database connection.
The name you enter will help you distinguish the Mobilty Work database from your other (future) data sources: please, choose an explicit name.
Enter the configuration parameters sent by Mobility Work
Click on the "Test DSN" button to test the correct connection to the database.
For the following screens, leave the default settings.
Your data source is added to your Windows.
Using data in Excel
Data menu>From other sources>From ODBC
Select the Mobility Work data source.
Enter the user name and password (supplied by Mobility Work) for database access.
Your Excel is now connected to the Mobility Work database.
For example, you can add one of these tables to a tab in your Excel spreadsheet.
Close and load
The data is present in your Excel spreadsheet.
Use the "Refresh" button to "refresh" your Excel data.
This will fetch updated data from the database.


title: Diet Soda is linked to Premature Births

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Diet Soda is linked to Premature Births
Diet Soda: Artificially sweetened soft drinks have been linked to high blood pressure and an increased risk of premature birth. A recent study examined almost 60,000 women at around 25 weeks of pregnancy. The women reported on their daily diet – specifically how many soft drinks they drank every day.
The study was conducted by the Statens Serum Institute in Copenhagen, Denmark. Lead Dr. Thorhallur I. Halldorsson said, “It may be non-optimal for pregnant women to have a high consumption of these types of products”.
Diet drinks sweetened with aspartame are considered to be good alternatives to their sugar-filled counterpart, but Halldorsson notes that there has been too little research on the safety of the consumption of artificial sweeteners. New studies have found a link between soft drinks and high blood pressure. High blood pressure increases the risk of premature birth.
After analyzing the results from the study of 60,000 pregnant women, it was found that 5% delivered their babies before 37 weeks. Women who had at least one serving of artificially sweetened soda a day while they were pregnant were 38% more likely to deliver their babies preterm than women who drank no diet soda at all.
The shocking find from the study was that women who had at least 4 diet sodas a day were 80% more likely to deliver preterm.
Only diet soda was linked to early delivery, not sugar-sweetened soda. The findings propose that the artificial sweetener itself is the cause of the findings. However, researchers say that other possible causes for the link cannot be ruled out.


title: What is yield to maturity ytm

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When it comes to fixed-income investments, such as bonds and investing in mutual funds, one of the most important metrics to understand is yield to maturity (YTM). But what is yield to maturity, and how does it impact your investment decisions? In this article, we’ll explore the YTM full form, its calculation, and how it affects your returns, especially when using a trading platform in India.
The YTM full form is Yield to Maturity. It indicates the overall anticipated return on a bond if it is held until its maturity date. The yield to maturity takes into account not only the interest (or coupon payments) a bondholder will receive but also any capital gain or loss that occurs when the bond is held until maturity.
YTM is the annualised rate of return an investor can expect to earn if they purchase a bond and hold it until the bond matures. This calculation includes the bond’s coupon payments, the difference between the purchase price and face value, and the time remaining until maturity. The YTM helps investors assess a bond's overall profitability compared to its face value and current market price.
The yield to maturity meaning encompasses several key components that investors need to understand:
Coupon payments are the interest amounts that the bond issuer pays to the bondholder. They are typically made semi-annually or annually and are fixed for the bond’s duration.
The price at which the bond is currently trading may be different from its face value (par value). YTM accounts for the difference between the current price and the face value. If the bond is purchased at a discount (below face value), the YTM will be higher than the coupon rate. When bought at a premium (above face value), the YTM will be reduced.
Yield to maturity also considers how much time is left until the bond matures. The longer the time to maturity, the greater the potential for price fluctuations, and this will impact the YTM.
YTM accounts for any capital gains or losses you may incur by holding the bond until it reaches maturity. If you buy the bond at a discount, you’ll realise a gain when it matures at face value, and if you buy it at a premium, you’ll experience a capital loss.
Calculating yield to maturity can be complex because it involves solving for the interest rate in the bond pricing formula. However, understanding how it’s calculated can provide insights into how YTM is used in decision-making.
Here’s the formula to calculate YTM:
YTM=[C + (FV – PV) ÷ n] ÷ [(FV + PV) ÷ 2]
Understanding what YTM is, is essential for bond investors because it helps you compare the potential returns on different bonds, even if they have different coupon rates, prices, and maturities. Here’s why yield to maturity is so important:
YTM allows investors to compare bonds with different coupon rates and prices. This helps in determining which bond provides the best return for the given market price.
Bonds with higher YTM typically offer higher returns, but they may also come with higher risk, especially if the bond is trading at a significant discount. YTM provides a more comprehensive view of the potential risk-reward balance than just looking at the coupon rate.
For long-term investors, yield to maturity provides a more accurate estimate of the bond’s return if it is held until maturity, making it easier to plan your investment strategy.
One common question is how yield to maturity differs from current yield. Although both assess bond returns, they are not identical:
Understanding what YTM is can help shape your investment strategy. Here’s how it influences decision-making:
When you’re investing in mutual funds that hold bonds, the YTM of the fund’s portfolio is often a key factor in determining the potential returns. A fund with a higher average YTM is likely to offer higher returns, but it may also carry higher risk.
For direct bond investors, YTM is crucial for assessing whether a bond is a good value. By comparing YTM across different bonds, investors can make more informed decisions about which bond offers the best return for its risk profile.
Understanding what is yield to maturity is critical for anyone involved in bond investing or investing in mutual funds. The yield to maturity meaning goes beyond just the coupon rate, providing a full picture of a bond’s potential returns. By learning how to interpret YTM and comparing it with other investment metrics, you can better assess risk and return, ensuring your fixed-income investments contribute to your long-term financial success.


title: Three reasons why saif is chinas top finance school

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He also has the distinction of being the first person from the People’s Republic of China to teach finance in a major American university and the first scholar to return and work in China on a full-time basis after becoming a tenured finance professor at a major American university.
We met the friendly professor when he was on a recent trip to London, and he told us why SAIF is bound to succeed, his return to China, and the uncertain future of finance.
SAIF was established two years ago with a mission to educate the men and women who will be running trading floors and investment banking divisions when Shanghai becomes a global financial center in 2020.
Chang told us what he thinks makes SAIF different to other business schools in China.
The first difference is that unlike other public institutions like Tsinghua University and Beijing University, where faculty hiring and tuition fees are set by the government, SAIF (which also receives government funding) has been given more freedom.
The SAIF executive team can hire faculty from abroad, with teaching and research experience in other countries, so teaching will be of an international standard.
Second, SAIF’s MBA is the only one specializing in finance, as opposed to a general management MBA.
Finally, the SAIF has set very high standards for teaching and research, hiring faculty from around the world to apply their knowledge to China’s environment.
Chang graduated in Mathematics from East China Normal University in 1982. His first love was social science, but at the time the economics taught at Chinese universities was, he said, “doctrine-based”.
He headed for the US, where he had a scholarship to study for an MSc in Math at the University of Oregon. He finally made the shift to business school when he was accepted for a PhD in finance and economics at the Kellogg School of Management In Chicago.
In 1987 he joined the faculty at the Carlson School of Management, at the University of Minnesota and stayed for 19 years, ending up as a chaired professor.
He returned to China in 2003, lured by an offer from the China Europe International Business School (CEIBS).
Now Chang’s priority is to find others as good as him and lure them back too.
He has already recruited four senior professors from the US. SAIF now has 25 full-time and special term professors and Chang’s goal is to double or triple the faculty within the next three years.


title: Top teacakes short and tweet

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I love a good tea-cake; toasted, lavishly buttered and enjoyed with a good mug of hot chocolate on a chilly winter's morning, it's the perfect way to start the day. Well, we haven't got the chilly mornings yet (not that you'll catch me complaining about that - I hate the cold!) but that just means that I'll have to make these again when such mornings roll around.
This week's 'Short and Tweet' challenge set up by @EvidenceMatters was to make Dan's Top Teacakes, to be found on page 88 of Short and Sweet or here, from the Guardian Guide to Baking.
I'm really glad that these were chosen for the challenge because I probably wouldn't have got round to making them otherwise. After all, I have been meaning to make them since November 2007, so I obviously needed an additional push! I think it was the scale of the recipe that put me off them - there is only me here to eat my baking efforts (although actually, my colleagues might quite like these!) so any bread recipe requiring 600g flour in addition to lots of other add ins and three eggs is going to take me a long time to get through. I decided to make 1/3 of the recipe (recipe uses three eggs, hence not halving it!) and also decided to make the teacakes much smaller. The recipe says nine, but I got six out of my 1/3 recipe, so mine are half of the recommended size. Having said that, these are still substantial buns, the original size must be massive!
I followed the recipe pretty closely (for me) - my kneading wasn't quite spaced as Dan instructed and I probably left the dough for about 1 1/2 hours in total for the first stage, and then nearly two hours at the second stage after shaping. My kitchen wasn't very warm, so I decided that after an hour I would encourage them a little by very briefly preheating my oven, turning it off and sticking them in there. This technique worked well, and I'll do it again.
For the ingredients, I used white chocolate, not beef dripping, raisins (roughly chopped) rather than currants, as I often find currants either seedy or stalky (whichever, they sometimes have nasty crunchy bits in them) and then used 1/4 tsp each ground ginger and mixed spice for the spices. Then, out of necessity rather than choice I used chopped dried cranberries instead of mixed peel. I discovered a while ago that whilst I hate chopped mixed peel, I really quite like candied peel that you can chop yourself. Sadly I haven't seen any in the supermarkets this year, and I'm upset that they seem to have stopped stocking it. If anyone has seen any, please let me know otherwise I'll have to investigate making my own!
I baked at 200C rather than 220C, (Gas 6 rather than Gas 7) because I always find these sweet, fruited breads colour too quickly when I bake at such a high temperature. That is also the case here, the buns are darker than I like, perhaps next time I'll try Gas 5. To compensate I baked for 20 minutes, turning the buns upside down after 15 minutes to brown the bases. It just means that they'll only need toasting on one side!
They're very tasty buns, but I do wish I hadn't darkened the crusts quite so much, I'm not a fan of dark crusts on sweet breads. The spice is very subtle, next time I might increase this a little more. The texture of these isn't the same as shop bought tea cakes, which are very light and fluffy. These are denser, but in a good way - after all, you need a good weight of bun to hold the melting butter and these are just right... There is plenty of fruit in the buns which is a good thing in my view, but again, I wish I had been able to get some mixed peel, there's just something delicious about the contrast of the slightly bitter mixed peel, the sweet bun and the rich melty butter.... mmm, melting butter!
Thanks to EM for picking these, and also to Jo for saying how lovely they were, without both of these prods to make them, I probably would still have left them.


title: Emily blunt to star in movie animal crackers with a list cast

text:
Emily Blunt has collaborated with her spouse John Krasinski for ‘Animal Crackers’.
The ‘Into The Woods’ performing artist and her 35-year-old hubby will both give their voices to the new toon.
The couple – who have a 13-month-old girl, Hazel, together – have joined the elegant thrown nearby Sylvester Stallone, Ian McKellen and Danny DeVito.
Emily who is 32, and ‘The Office’ star will play on-screen couple Zoe and Owen Huntington who acquire a bazaar and end up changed into different animals in the wake of devouring creature molded scones.
News the pair were to show up in the movement was reported by the film’s co-chiefs Scott Christain Sava and Tony Bancroft, who accept the couple are ideal for the parts.
Sava told Screen International: ”When Emily and John came in and performed their first scenes of the film together… It was enchantment.
”I can think about no other method for portraying what they conveyed to the film. We needed to actually do a reversal and re-storyboard the arrangements in light of the fact that they took us to places we never envisioned. Owen and Zoe became animated when Emily and John talked.”
Harvey Fierstein, Patrick Warburton, Tara Strong and Lydia Taylor additionally star in the motion picture which is situated to hit silver screens one year from now.
MARKMEETS have been online since 2004, and provide the latest UK Entertainment News, celeb interviews, info on film premieres, competitions, movie news, celeb photos, music videos and all things celebrity.
“Leading The Way In Entertainment”. – MarkMeets


title: South african government officials debate grace immunity

text:
South African officials are debating whether to grant diplomatic immunity to Zimbabwe’s first lady Grace Mugabe who is accused of assaulting a 20-year-old model in Johannesburg earlier this week.
Mugabe is still in South Africa after a day of intense speculation over her whereabouts, South African police said in a Wednesday statement.
The police said the Zimbabwean government asked for diplomatic immunity for a suspect involved in the alleged assault. The police have declined to name Mugabe in the case as she has not yet appeared in court.
Mugabe’s immunity request is currently under consideration, Clayson Monyela, a spokesperson for the Department of International Relations and Cooperation told The Associated Press.
Acting national police commissioner Lesetja Mothiba said earlier on Wednesday that police and national prosecutors wanted to charge Mugabe, according to the African News Agency. “Our position was that she must go to court,” he said.
Gabriella Engels registered a case with police on Monday accusing Mugabe, 52, of attacking her with an extension cord in a luxury hotel in a Johannesburg suburb late on Sunday evening.
Engels said she been in a hotel room with mutual friends of Mugabe’s two sons, who live in Johannesburg, when the first lady burst into the room and allegedly assaulted her.
Photos of Engels posted on social media show a bloody gash to her forehead that she claimed was a result of the encounter.
Confusion over whether Mugabe was still in the country flared up on Tuesday after South Africa’s police minister said she was due to appear in a South African court and she did not show up, fueling speculation she may have returned to Zimbabwe.
Police clarified on Wednesday that while the suspect had failed to present herself to police to obtain a “warning statement” about the case, she remained in the country and had sent her lawyers and Zimbabwe government officials to tell police she intended to request diplomatic immunity.
“Discussions with the suspect’s lawyers and the Zimbabwean High Commission representatives are taking place to make sure that the suspect is processed through the legal system,” the police statement said.
Engels told the AP she would be willing to face Mugabe in court.
“I want to go to court because I really feel like she should go to jail for what she did to me,” she said. “I don’t want her to get away with this. Because what happened to me was not OK.”
Mugabe has been accused of assaults during other overseas trips, including a 2009 visit to Hong Kong in which a photographer accused her of beating him up.
President Robert Mugabe is expected to join his wife in South Africa to attend the summit of the Southern African Development Community (SADC) later this week.


title: Lxi compliant switching matrices handle high voltages

text:
Pickering Interfaces is expanding its range of LXI-compliant switching products with the introduction of the 60-310 high-voltage matrix and the 60-510 LXI low thermal EMF matrix.
The 60-310 is a high-voltage 300 X 2 two-pole switching matrix capable of hot switching 500V DC signals and cold switching 1000V DC signals. The matrix is contained within a compact 2U full rack-width enclosure. The 60-310 is suitable for performing insulation tests on cable harnesses and PCBs, and for testing for breakdown voltages of semiconductor devices and relays. Its design uses Rhodium-plated reed relays that are optimised for high-voltage switching applications requiring a long service life.
The 60-510 is a low thermal EMF 56x33 matrix capable of switching 150V DC signals with carry current up to 1A. The matrix is contained within a compact 2U full rack-width enclosure. It uses instrument-grade Ruthenium sputtered relays to ensure a very long service life with very good low-level switching performance and ultra-stable contact resistance stability, while typically providing less than 2.5mV of thermal EMF.
Both products are supplied with IVI, SOAP and Direct I/O drivers and soft front panels that allow them to be controlled through any W3C-compliant web browser.
The products are the latest in an expanding range of LXI-compliant switching products available from Pickering Interfaces. David Owen, Business Development Manager for Pickering Interfaces, comments: "LXI is a rapidly growing part of our business. It has gone from nothing to being a significant proportion of revenue in less than 18 months and sales have been particularly strong in Europe. We are seeing a rapidly growing adoption of LXI in the test and measurement industry and Pickering Interfaces is fully committed to building a strong LXI business to compliment its PXI business.
"The recent successful LXI meeting in China supported by Pickering Interfaces shows that LXI will become a global standard for the test and measurement industry".
These products are available now and pricing can be found on Pickering's website.
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title: 09

text:
This is my try at a simple authoritative server: where the clients send their commands to the server, the server decides where everyone moves to on the map and sends back the location of all clients to everyone. There is no delta compression when serializing, no client-side prediction or server reconciliation, no lag compensation. In other words: very very simple.
In the picture you can see red capsules (on the Host) that show where the server says everyone is. We do our physics movement on these objects.
The blue capsules are where the server is telling clients everyone is. They have no physics associated with them, they are just moved to the locations received in a message every 1/20 seconds. Notice that the client window has no red capsules: this is because it is not a server and is not calculating where everyone is.
There are six scripts in this project.
Defines the PlayerCmd type which is what the client sends to the server (mouseButton0, horizontal, vertical, jumpButton)
Defines the PlayerState type which is sent from the server to the clients (List of clientId, position, rotation)
Defines PlayerObjectDictionary which is how a server keeps track of all non-networked red capsules and how clients keep track of non-networked blue capsules
There is code in here that explains to MLAPI how to serialize PlayerCmd and PlayerState over the network
The client will save inputs to PlayerCmd every 0.01 sec. After it has saved 5, it sends out an array of PlayerCmds to the server (every 1/20 sec)
Server code is in this file as well. It shows the server saving a client PlayerCmd to a dictionary (uses clientId as a key)
This is where the server has a bunch of fake red gameObjects representing clients that it moves around. It is using Unity’s CharacterController to figure out where the objects move. It uses input from each client’s PlayerCmds array.
After 1/20 sec has passed, the code sends out a PlayerState to all clients which is a List of the locations of all clients.
This is where the client receives the PlayerState List from the server. It will take each PlayerState and create a fake blue gameObject that represents that client. It simply Lerps each transform to the location reported by the server.
This is attached to the fake blue gameObject that ClientPlayerObjects creates that shares our clientId.
Displays a menu and bytes sent/received. Note the bytes sent/recv seems to be broken in MLAPI?
The Issue of Networking
The client records user input every 0.01 sec to a PlayerState. Every 0.05 sec it sends this size 5 array to the server. Perfect world: the server takes index 0 and moves the red client object between time 0.0 and 0.01 sec. Between 0.01 and 0.02 it uses index 1, etc. The server sends a record of where every red gameObject was calculated to be to the clients every 0.05 sec. We are using MLAPI and transport Ruffles. We can turn on the Simulator and make it so PlayerState doesn’t get to the server all the time, that messages are delayed, etc. So what we do on the server is (currently) use index 0 between time 0.0 and 0.02 sec (double!), then use index 1 from 0.02 and 0.04, index 2 from 0.04 to 0.06. We still have 2 more PlayerStates we can use. Hopefully by this time a new PlayerState set has arrived from the client. If it hasn’t, we will continue to use the last index 4 to move our red client object. Networking is hard.
Pretty much the same as the Simple MLAPI Test, with these differences:
Window > MLAPI > Transports > Ruffles > Install Latest GameObject > NetworkingManager > Select transport... > RufflesTransport NetworkingManager > Create Player Prefab > Off (We are not using any NetworkTransport) Ruffles Transport > Log Level > Warning Ruffles Transport > Simulator > Use Simulator (If you want) Layer > Add Layer... > Added "Server", "Client", and "Local" Edit > Project Settings... > Physics > Uncheck Server/Local, etc. (We don't want Host w/ client and server obj to interact) Important: Attach a Player prefab to ClientPlayerObjects > playerPrefab
There’s a lot wrong here. I really struggled with how Unity organizes things vs. a regular C# project with classes. The hardest part of this small project was just trying to organize each script in a logical way! I have a CustomTypes which is used by two other classes but does nothing itself, really. I have a ThirdPersonCamera that needs ClientPlayerObjects to set what it points at. I have HandlePlayerCmds that remembers (on server) what all client input was, and that’s used by ServerPlayerObjects. I have classes exposing “static public” variables for ease of use.
For the networking memory usage, we create a new List every time we send out/receive PlayerState. Create a new array of PlayerCmds when those come in. We constantly send PlayerState even if the player is standing there. This stuff really bothered me.


title: Dysport in pune

text:
Dysport is an injectable treatment for wrinkles and frown lines located between the eyebrows. One twenty-minute treatment can last up to four months. The difference with the Dysport formula is that untreated muscles continue to work normally. That translates to a natural look because facial expressions are unimpeded. There is no frozen effect when Dysport is used. People can be as expressive as they want to be and still have younger looking skin without deep creases between the eyebrows. Investigating the use of this treatment early will contribute to the more natural look. Waiting until those lines are pronounced means the effect will be more noticeable once the injection is given.
Injectable facial treatments to minimize the appearances of aging are gaining in popularity. New formulas, advanced technology, and affordable pricing makes them an ideal alternative to invasive plastic surgery. There is no recovery time, side effects are minimal, and there are no scalpels involved. Most treatments last for ten to fifteen minutes per session.
People who are constantly having injections to different areas of the face often suffer from a semi-frozen look. Muscles and skin are filled or plumped too much and it is next to impossible to alter facial expressions. This one of the largest reasons men and women choose Sparsh Clinic. Since most treatments are not permanent, maintenance injections are being done somewhere on the face at regular intervals. Collagen for the lips, gels for crow feet, and serums for laugh lines all look better with scheduled consultations for further treatment by our professionals.
Treating lines when they first begin to appear will provide a subtle result that most people will not even realize. They will continue to see the face as young and fresh. No one will know a treatment was completed unless you tell them. Since treatments are only done a few times a year, costs are manageable.


title: Why buying a home still makes better financial sense than renting

text:
Both house and rental prices have risen, pushing many to contemplate the benefits of buying vs. renting in 2022. Renting is usually the more affordable option, but with rent payments being nearly equal to buying a home, is waiting to buy a home even worth it?
Don’t worry because several significant differences could make purchasing your own home a better choice for you. Let’s break it down…
Having Your Own House Allows You to Build Wealth
Owning a home is a clever way to build lifelong wealth. A house is a valuable asset — its value is more than just a place to reside in.
It’s been known that real estate properties’ value grows over time or appreciates. No other assets can top owning a house to build your wealth more consistently. If you rent, you’re building your landlord’s wealth, not your own.
Purchasing your property and taking care of it for the long-term guarantees its value will grow over time. Property ownership is one of the best ways to build sustainable wealth –but you don’t have to be wealthy to get started.
Just one home, your primary home, is sufficient enough to make a real difference in your personal wealth.
In Long-Term, Purchasing a Home is More Affordable than Renting
The cash you use for paying rental costs is money you can’t get back. When you rent a home, you make monthly payments for a house that’s not yours, which means you don’t build equity.
A house is a huge purchase, but considering the ever-increasing rent you have to pay, purchasing and owning a home will eventually be more affordable.
In many instances, purchasing a house can be similar to rental costs. And paying off a home you own is ten times better than paying off your landlord’s asset.
Purchasing a House Gives You Stability
Most homeowners will concur that the peace, privacy, and stability of having a house is worth it. Buying a property means your kids will always have a place to call home, create lifelong friends with those who live close to your area, and be a part of the community for generations to come.
Buying a House Decreases Your Living Expenses Significantly
For many Americans, the concept of living mortgage-free or rent-free is very enticing. You wouldn’t be able to do this if you chose to rent a house.
Obviously, you will still have to be responsible for paying insurance and property taxes, but those expenses are way cheaper compared to making monthly rental payments.
The Bottom Line
If you’re still contemplating if you should rent or buy, work with our mortgage experts to explore your options. With home equity and protection against inflation on the line, it might make more financial sense to purchase a house if you can buy one.


title: Summer 2023 arrangements confirmed for gcse as and a levels

text:
DfE and Ofqual have now confirmed the exam arrangements for students taking exams in Summer 2023: “GCSE, AS and A Level exams in England will largely return to pre-pandemic arrangements next summer as young people continue to recover from the pandemic.” Ofqual has also confirmed a return to pre-pandemic grading in the June 2023 series.
DfE and Ofqual have launched a number of consultations around the support to protect students from the disruption of the last few years. They have confirmed this does not include advance information of exam content. The consultations relating to OCR qualifications are:
You have until 20 October at 11:45 pm to respond to these consultations.
Following the announcement from DfE and Ofqual, we have now published the provisional June 2023 timetables. If you have any comments on the timetables, please send your feedback to the JCQ at email@example.com by 13 October 2022.
Results days will be on 17 August 2023 for AS and A Levels and 24 August 2023 for GCSEs.
The JCQ has confirmed the arrangements from summer 2022 will be carried forward to all future exam series – where a student is absent from an exam or assessment for an acceptable reason, they could receive a grade as long as they had completed at least one entire component of a qualification. This replaces the previous requirement for students to complete at least 25% of a qualification.
See our separate news story for the arrangements for Cambridge Nationals and Cambridge Technicals.
If you have any questions about what you have read here, please get in touch by calling us on 01223 553998 or email at firstname.lastname@example.org.


title: Agios georgios 3 bedroom bungalow mls 911

text:
SOLD – Modern 3 bedroom detached bungalow in a quiet residential cul-de-sac in the highly desirable neighbourhood of Agios Georgios.
The area, well known for its luxury properties, has a quaint harbour, selection of local tavernas, international school, and the beautiful Akamas Peninsula nearby, all of which are within easy walking distance. The holiday resort of Coral Bay and Peyia Village with all its amenities are just a few minutes’ drives away.
This Property is NOW SOLD!
For those seeking a quality residence in a tranquil area of outstanding natural beauty near the coast, this home is certainly a perfect option.
Equally suitable as a permanent residence or beautiful holiday home this immaculately presented property is situated in a fabulous setting on a fully enclosed 450 sqm plot. Maintained to an exceptional standard it features many additional home comforts and quality fittings & finishes throughout.
The living accommodation includes a spacious open plan living room with comfortable lounge, formal dining area and fully fitted kitchen. The lounge is bright and airy with high ceilings and light floods in on each side through 3 sets of sliding patio doors which also prove easy access to the outdoor leisure space.
The stylish kitchen has an abundance of fitted base and wall units plus a useful breakfast bar with built-in storage and quality granite finish. Kitchen appliances include fridge/freezer, built-in oven, ceramic hob, extractor fan, microwave and washing machine and there is also space to accommodate a dishwasher if required.
An inner hallway with additional built-in storage and linen cupboards leads to the master bedroom with en-suite shower room, a further two double bedrooms and a separate family size bathroom. All bedrooms feature modern white fitted wardrobes, air conditioning and fly screens.
Externally the low maintenance landscaped garden offers a variety of seating/dining areas with a covered pergola and gazebo providing welcome shade from the hot sun. A crystal clear 10 m x 4 m swimming pool with sunbathing terrace provides the perfect spot to cool off in the hot summer plus a generous size roof terrace reached via a spiral staircase, offers further space to relax and enjoy the stunning coastal views and amazing sunsets.
A gated driveway with car port to the side of the property has parking space for 2 cars and can be extended if required.
There are full title deeds and some furniture can be included if required.
Agios Georgios Property Details
- Property ID:101-911
- Property Size:118 Sqm
- Land Area:450 Sqm
- Year Built:2004
- Property Status:Sold


title: Her broadway musical here lies love

text:
H.E.R. is set to join the upcoming Broadway musical “Here Lies Love” as a producer.
The musical, whose official opening night is scheduled for July 20, tells the story of the Philippines’ former First Lady Imelda Marcos and how she fell from power following the 1986 People Power Revolution.
“Filipinos are a global people. We come in all colors and build bridges across cultures. I am beyond excited to produce my first Broadway musical and forge a unique and meaningful partnership with ‘Here Lies Love,'” H.E.R., 25, said in a recent statement.
H.E.R., who has five Grammys, an Oscar and an Emmy under her belt, is no stranger to theater.
Tony and Olivier Award-winner Lea Salonga, who will also be producing “Here Lies Love,” praised H.E.R. in a recent statement.
On behalf of our binational producing team, we welcome Gabi [H.E.R., who was born Gabriella Wilson] to the ‘Here Lies Love’ team with open arms! I am a huge fan of her genre-defying and multifaceted artistry, and it’s empowering to welcome another Filipino artist to our ranks. Together, we are throwing the biggest party Broadway has ever seen – and everyone is invited!
In addition to producing, the 52-year-old star is notably set to make a guest appearance in the musical from July 11 to August 13. This will mark her first Filipino role in a Broadway musical, as well as her return to the Broadway Theatre, where she made her Broadway debut as Kim in “Miss Saigon” in 1991.
“Here Lies Love,” which was created by musicians David Byrne and Fatboy Slim, premiered off-Broadway at The Public Theater in 2013.
It would run again at the same theater from 2014 and 2015 before being picked up for Broadway.
In addition to Salonga, other stars from the Philippines will appear in the musical this summer, including Jose Llana and Conrad Ricamora.


title: Prison for man who fired shots at ballygawley bar

text:
A 52-YEAR-OLD man who fired shots into a Ballygawley bar after an earlier dispute, putting many people in peril, has been jailed.
Robert McCrum (52), of Eskragh Terrace, Dungannon, admitted possessing a shotgun and a handgun to cause fear of violence, affray and damaging a window.
Offending occurred on August 28, 2022 at Tailor’s House, and, in the aftermath, McCrum fled the scene, but later handed himself in to police.
He had been in the bar earlier but left following a disagreement, returning a short time later.
CCTV footage showed a car driven by McCrum in possession of two firearms.
A shot was fired from the driver’s side, followed by a second smashing a window in the premises.
McCrum, who held a firearms certificate, attended a friend’s home and asked him to store two guns, before travelling to the Republic of Ireland.
On August 29, 2022, police issued an alert for his welfare, and three days later he surrendered and was arrested.
During interview, McCrum gave an account, but police said they were of the opinion it didn’t stand up to scrutiny.
When charged, a detective informed the court that McCrum was head of a gun club and would have easy access to firearms may carry out further offences.
“He claims to have travelled to Slane in the hours after the shooting to attend a motorbike show outside the jurisdiction,” the detective added.
The defence pointed out McCrum attended with police of his own volition to make a complaint against a person in the bar, and was arrested.
While bail was initially refused, McCrum was later released by the High Court.
The case transferred to Dungannon Crown Court, where sentencing was scheduled to take place last month when a defence barrister pointed out McCrum was in a wheelchair.
Judge Fiona Bagnall enquired, “Has his condition deteriorated, because I think I gave him a bail variation to go to watch motorbike racing?”
Prosecuting counsel added, “I understand the defendant has a prosthetic leg, and when he doesn’t have that, he’d need a wheelchair. However, in footage of the incident, he had his prosthetic leg and was able to move about.”
There were also issues around character references provided to the court, which the prosecution were unaware of.
The case was adjourned, and, upon return, the defence highlighted McCrum’s guilty plea and his presentation as ‘contrite and remorseful’.
“Alcohol was a factor in the offending and the run-up to it. This would not have occurred but for alcohol and immediate, ready access to firearms.”
It was stressed that the defendant has misused alcohol for years, and had some ‘deficiencies in intellectual capacity’, which the defence originally suggested may have caused concerns over fitness to plead.
Despite this, McCrum was deemed suitable to hold a firearms licence.
However, since offending, all guns were seized, and he is unlikely to be permitted access again.
It was accepted the custody threshold was passed. However, in arguing for this to be suspended the defence pointed to, “Exceptionality in the fact the firearms were legally held. Nobody was injured and damage was limited”.
Judge Bagnall noted after being asked to leave the bar, McCrum, “Deliberately returned with two firearms, both of which were discharged. I can draw no other conclusion than this was a genuine attempt to frighten those at the bar … Fortunately no-one was injured, but given the nature of the incident, it would appear that those who witnessed suffered distress and upset.”
She imposed a sentence of two years and two months.
McCrum was also ordered to pay £1,000 compensation and the guns used in the offence will be destroyed.
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title: Research reveals how disordered protein interaction orchestrates gene expression

text:
A team led by researchers at Baylor College of Medicine and the Czech Academy of Sciences has uncovered a new piece of the puzzle of how gene expression is orchestrated. Published in the journal Science, the findings reveal a novel mechanism that coordinates the assembly of components inside cells that control gene expression. The mechanism not only is essential for normal cell function, but also has been implicated in cancer, neurodegeneration and HIV infection, and could suggest new ways to treat these conditions.
Most previous studies have focused on particular cellular components that turn genes completely on or off. Our work reveals a new perspective – that the proteins that regulate the rate of gene expression also can work collectively to finely tune expression levels in many different settings. We identified a mechanism that brings these proteins together and plays widespread roles in health and disease."
Dr. H. Courtney Hodges, co-corresponding author, assistant professor of molecular and cellular biology, Center for Precision Environmental Health, Baylor College of Medicine
In previous work with colleagues at KU Leuven in Belgium, the team had studied protein interactions in leukemia and HIV infection, specifically those mediated by protein regions called TFIIS N-terminal domains (TNDs). In the current study, the researchers extended the study of TNDs and found them in many other proteins.
"Everywhere we looked, we found these domains, in particular in the machinery that regulates transcription elongation, one of the first steps of gene expression in all human cells. Transcription elongation is a complex cellular process that involves many different proteins working together," said first author Dr. Katerina Cermakova, a postdoctoral fellow in the Hodges lab. "We discovered that TNDs are the most enriched structural element in all transcription elongation factors. Once you look for them, you find that all the important protein complexes involved in transcription elongation have a TND or bind a protein that has one."
Previous work suggested to the researchers that TNDs act like a docking platform for other protein regions, specifically for small portions of unstructured proteins known as TND-interacting motifs (TIMs).
Proteins have segments with a well-organized 3-D structure, but many also have segments that lack such organization. These disordered or unstructured regions are often functional.
"One remarkable thing about these unstructured regions is their unusual behavior as molecules," said co-corresponding author Dr. Vaclav Veverka, structural biologist and group leader at the Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences (IOCB Prague). "Imagine a TIM as a string that is loose at one end and moves as if being blown around in a hurricane. But when it finds its TND partner, the string curls up and holds on very tightly to the TND to keep it close." The researchers show this attachment plays an important role in the early stages of gene expression.
"We first determined that TNDs and TIMs bound together in 'test tube' type of experiments, but it was really exciting to see that they bind to each other in living cells, validating the relevance of our observations in living systems," Cermakova said. "We also determined that the TND-TIM interactions are highly specific."
"I was surprised to see that IWS1, a protein previously thought to be a secondary player in the transcription elongation machinery, acts as a central organizer of these factors," said Hodges, a member of Baylor's Dan L Duncan Comprehensive Cancer Center.
"We found that IWS1 uses specific TND-TIM interactions to coordinate the activities of many transcription regulators at the same time, making it appear like a conductor at a symphony that keeps all the factors working in harmony and close by," Veverka said.
The team also explored the consequences of disrupting a single unstructured protein region on the harmony of the transcription elongation process.
"Hundreds of genes with important functions were altered when we disrupted even a single unstructured region," Hodges said. "The first step of gene expression started, but was paused and unable to be completed, preventing efficient gene expression."
The study highlights the underappreciated role of disordered protein interactions as key orchestrators in gene expression and other complex biological functions. The findings also can contribute to a better understanding of diseases such as cancer, viral infections, neurodevelopmental disorders and potentially other conditions in which these factors are disrupted. TNDs and TIMs may represent important novel targets for improved treatments for these conditions.
Baylor College of Medicine
Cermakova, K., et al. (2021) A ubiquitous disordered protein interaction module orchestrates transcription elongation. Science. doi.org/10.1126/science.abe2913.
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